Title:
COMPLEX IN WHICH AN ANTI-COTININE ANTIBODY IS BOUND TO A BINDER MATERIAL OF COTININE AND A BINDING SUBSTANCE, AND A USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2012/141554
Kind Code:
A2
Abstract:
The present invention relates to a complex in which an anti-cotinine antibody is bound to a binder material comprising a binding substance and cotinine, and relates to a use therefor. The binder material according to the present invention can be used as an analysis tool in an in vitro biological assay, and can retain the specific reactivity and biological functions of the binding substance, and the inherent characteristic complement-dependent cytotoxicity (CDC), antibody dependent cell-mediated cytotoxicity (ADCC) and long in vivo half life of the antibody.
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Inventors:
CHUNG JUNHO (KR)
PARK SUNYOUNG (KR)
HWANG DO BEEN (KR)
LEE HWA KYOUNG (KR)
PARK SUNYOUNG (KR)
HWANG DO BEEN (KR)
LEE HWA KYOUNG (KR)
Application Number:
PCT/KR2012/002873
Publication Date:
October 18, 2012
Filing Date:
April 16, 2012
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
CHUNG JUNHO (KR)
PARK SUNYOUNG (KR)
HWANG DO BEEN (KR)
LEE HWA KYOUNG (KR)
CHUNG JUNHO (KR)
PARK SUNYOUNG (KR)
HWANG DO BEEN (KR)
LEE HWA KYOUNG (KR)
International Classes:
C07K16/44; C07D401/04; C07K14/575; C07K17/02; C12N15/115; G01N33/53
Domestic Patent References:
| WO2002049667A2 | 2002-06-27 |
Foreign References:
| US8008448B2 | 2011-08-30 | |||
| US6355245B1 | 2002-03-12 |
Other References:
SATO A.K. ET AL., CURR OPIN BIOTECHNOL, vol. 17, 2006, pages 638 - 642
VERONESE, F. M.; PASUT G., DRUG DISCOV TODAY, vol. 10, 2005, pages 1451 - 1458
RIAH O. ET AL., TOXICOL. LETT., vol. 109, 1999, pages 21 - 29
BOWMAN, E.R.; MC, K.H., JR., J PHARMAEOL. EXP. THER., vol. 135, 1962, pages 306 - 311
BENOWITZ N.L ET AL.: "3rd Handb. Exp. Pharmaeol.", 2009, pages: 29 - 60
HATSUKAMI, D.K. ET AL., PHARMAEOL. BIOCHEM. BEHAV., vol. 57, 1997, pages 643 - 650
NICOL DS; SMITH, LF., NATURE, vol. 187, 6 August 1960 (1960-08-06), pages 483 - 5
BAEK SH ET AL., J BIOL CHEM., vol. 271, no. 14, 5 April 1996 (1996-04-05), pages 8170 - 5
KIM SD ET AL., J IMMUNOL., vol. 183, no. 9, 1 November 2009 (2009-11-01), pages 5511 - 7
PARK S ET AL., CLIN CHIM ACTA., vol. 411, no. 17-18, 11 May 2010 (2010-05-11), pages 1238 - 42
BARBAS ET AL., PROC. NATL. ACAD. SCI., USA, vol. 88, no. 18, 15 December 1990 (1990-12-15), pages 7978 - 7982
YOE-SIK BAE ET AL., J IMMUNOL., vol. 173, 2004, pages 607 - 614
GRYNKIEWICZ G. ET AL., JBIOL CHEM., vol. 260, 1985, pages 3440 - 3450
BAE ET AL., BLOOD, vol. 97, 2001, pages 2854 - 2862
See also references of EP 2700653A4
VERONESE, F. M.; PASUT G., DRUG DISCOV TODAY, vol. 10, 2005, pages 1451 - 1458
RIAH O. ET AL., TOXICOL. LETT., vol. 109, 1999, pages 21 - 29
BOWMAN, E.R.; MC, K.H., JR., J PHARMAEOL. EXP. THER., vol. 135, 1962, pages 306 - 311
BENOWITZ N.L ET AL.: "3rd Handb. Exp. Pharmaeol.", 2009, pages: 29 - 60
HATSUKAMI, D.K. ET AL., PHARMAEOL. BIOCHEM. BEHAV., vol. 57, 1997, pages 643 - 650
NICOL DS; SMITH, LF., NATURE, vol. 187, 6 August 1960 (1960-08-06), pages 483 - 5
BAEK SH ET AL., J BIOL CHEM., vol. 271, no. 14, 5 April 1996 (1996-04-05), pages 8170 - 5
KIM SD ET AL., J IMMUNOL., vol. 183, no. 9, 1 November 2009 (2009-11-01), pages 5511 - 7
PARK S ET AL., CLIN CHIM ACTA., vol. 411, no. 17-18, 11 May 2010 (2010-05-11), pages 1238 - 42
BARBAS ET AL., PROC. NATL. ACAD. SCI., USA, vol. 88, no. 18, 15 December 1990 (1990-12-15), pages 7978 - 7982
YOE-SIK BAE ET AL., J IMMUNOL., vol. 173, 2004, pages 607 - 614
GRYNKIEWICZ G. ET AL., JBIOL CHEM., vol. 260, 1985, pages 3440 - 3450
BAE ET AL., BLOOD, vol. 97, 2001, pages 2854 - 2862
See also references of EP 2700653A4
Attorney, Agent or Firm:
FIRSTLAW P.C. (275-7 Yangjae-Dong Seocho-Ku, Seoul 137-739, KR)
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Claims: