Title:
COMPLEX, METHOD FOR PRODUCING COMPLEX, AND COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/181695
Kind Code:
A1
Abstract:
The purpose of the present disclosure is to provide: a complex of a cell and a material; a method for producing a complex of a cell and a material; and a novel compound that can be used to obtain said complex. In a complex according to this embodiment, a cell having an azido group on the cell surface and a material having an azido group (excluding a fluorescent dye having an azido group) are bonded to each other by means of dibenzocyclooctadiene having a polar functional group.
Inventors:
TERA MASAYUKI (JP)
KITAGAWA KOHEI (JP)
YOSHINAGA MOEKA (JP)
MATSUZAKI TAKAHISA (JP)
OKUMA NAO (JP)
YOSHIKAWA HIROSHI (JP)
KITAGAWA KOHEI (JP)
YOSHINAGA MOEKA (JP)
MATSUZAKI TAKAHISA (JP)
OKUMA NAO (JP)
YOSHIKAWA HIROSHI (JP)
Application Number:
PCT/JP2022/007624
Publication Date:
September 01, 2022
Filing Date:
February 24, 2022
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP)
International Classes:
C12N11/14; C07C217/24; C07C275/10; C07C279/14; C07C309/11; C07C309/14; C07F9/09; C07H15/24; C12N1/14; C12N1/20; C12N5/04; C12N5/07; C12N11/16
Domestic Patent References:
| WO2011118394A1 | 2011-09-29 | |||
| WO2020002469A1 | 2020-01-02 |
Other References:
MASAYUKI TERA, ZAHRA HARATI TAJI, NATHAN W. LUEDTKE: "Intercalation-enhanced “Click” Crosslinking of DNA", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, vol. 57, no. 47, 19 November 2018 (2018-11-19), pages 15405 - 15409, XP055589511, ISSN: 1433-7851, DOI: 10.1002/anie.201808054
SHARMA KRISHNA, STRIZHAK ALEXANDER V., FOWLER ELAINE, WANG XUELU, XU WENSHU, HATT JENSEN CLAUS, WU YUTENG, SORE HANNAH F., LAU YU : "Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 17, no. 34, 28 August 2019 (2019-08-28), pages 8014 - 8018, XP055961525, ISSN: 1477-0520, DOI: 10.1039/C9OB01745C
DEWEY A. SUTTON, SEOK-HO YU, RICHARD STEET, VLADIMIR V. POPIK: "Cyclopropenone-caged Sondheimer diyne (dibenzo[a,e]cyclooctadiyne): a photoactivatable linchpin for efficient SPAAC crosslinking", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 52, no. 3, 1 January 2016 (2016-01-01), UK , pages 553 - 556, XP055589528, ISSN: 1359-7345, DOI: 10.1039/C5CC08106H
KOHEI KITAGAWA, NAHO OKUMA, KENJU MATSUZAKI, HIROSHI YOSHIKAWA, MASAMI SUGANUMA, MASAYUKI TERA: "A24-3am-08 Cell surface modification using water-soluble strained diyne", BOOK OF ABSTRACTS, THE 101ST CSJ ANNUAL MEETING (2021); MARCH 19-22, 2021, CHEMICAL SOCIETY OF JAPAN, JP, 4 March 2021 (2021-03-04) - 22 March 2021 (2021-03-22), JP, pages A24 - 3am, XP009539388
SHARMA KRISHNA, STRIZHAK ALEXANDER V., FOWLER ELAINE, WANG XUELU, XU WENSHU, HATT JENSEN CLAUS, WU YUTENG, SORE HANNAH F., LAU YU : "Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 17, no. 34, 28 August 2019 (2019-08-28), pages 8014 - 8018, XP055961525, ISSN: 1477-0520, DOI: 10.1039/C9OB01745C
DEWEY A. SUTTON, SEOK-HO YU, RICHARD STEET, VLADIMIR V. POPIK: "Cyclopropenone-caged Sondheimer diyne (dibenzo[a,e]cyclooctadiyne): a photoactivatable linchpin for efficient SPAAC crosslinking", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 52, no. 3, 1 January 2016 (2016-01-01), UK , pages 553 - 556, XP055589528, ISSN: 1359-7345, DOI: 10.1039/C5CC08106H
KOHEI KITAGAWA, NAHO OKUMA, KENJU MATSUZAKI, HIROSHI YOSHIKAWA, MASAMI SUGANUMA, MASAYUKI TERA: "A24-3am-08 Cell surface modification using water-soluble strained diyne", BOOK OF ABSTRACTS, THE 101ST CSJ ANNUAL MEETING (2021); MARCH 19-22, 2021, CHEMICAL SOCIETY OF JAPAN, JP, 4 March 2021 (2021-03-04) - 22 March 2021 (2021-03-22), JP, pages A24 - 3am, XP009539388
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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