Title:
COMPOSITION COMPRISING OSTEOPONTIN INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTION, ALLEVIATION, OR TREATMENT OF NEURODEGENERATIVE DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/246744
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising an agent inhibiting gene expression or protein activity of osteopontin as an active ingredient for preventing or treating neurodegenerative disease. According to the present invention, there is an effect of suppressing amyloid beta (Aβ)-induced neuronal cell death by downregulating the expression or activity of osteopontin. In addition, an inhibitor against the expression or activity of osteopontin decreases a level of pro-inflammatory proteins and conversely, increases a level of anti-inflammatory proteins. Therefore, it is expected that the present invention can be advantageously used as a therapeutic agent for various neurodegenerative diseases including Alzheimer's disease.
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Inventors:
KIM SUNG WON (KR)
PARK SOON A (KR)
LEE JUNG EUN (KR)
JEUN SIN-SOO (KR)
LIM JUNG YEON (KR)
YANG SEUNG HO (KR)
PARK SOON A (KR)
LEE JUNG EUN (KR)
JEUN SIN-SOO (KR)
LIM JUNG YEON (KR)
YANG SEUNG HO (KR)
Application Number:
PCT/KR2021/006768
Publication Date:
December 09, 2021
Filing Date:
June 01, 2021
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K35/32; A23L33/10; A61P25/28; G01N33/50; G01N33/68
Foreign References:
| US20110092575A1 | 2011-04-21 | |||
| KR20190009374A | 2019-01-28 | |||
| KR100947424B1 | 2010-03-12 | |||
| KR20200066649A | 2020-06-10 | |||
| KR20210069644A | 2021-06-11 |
Other References:
CHABAS DOROTHEE ET AL: "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 294, no. 5547, 23 November 2001 (2001-11-23), US , pages 1731 - 1735, XP002299870, ISSN: 0036-8075, DOI: 10.1126/science.1062960
DATABASE PROTEIN 25 July 2016 (2016-07-25), ANONYMOUS : "Homo sapiens secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early Tlymphocyte activation 1), partial [synthetic construct]", XP055877290, retrieved from NCBI Database accession no. AAP36151
BARTELDP ET AL., CELL, vol. 116, no. 2, 2004, pages 281 - 297
NIELSEN PEEGHOLM MBERG RHBUCHARDT O: "Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide", SCIENCE, vol. 254, no. 5037, December 1991 (1991-12-01), pages 1497 - 1500, XP002912953, DOI: 10.1126/science.1962210
DATABASE PROTEIN 25 July 2016 (2016-07-25), ANONYMOUS : "Homo sapiens secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early Tlymphocyte activation 1), partial [synthetic construct]", XP055877290, retrieved from NCBI Database accession no. AAP36151
BARTELDP ET AL., CELL, vol. 116, no. 2, 2004, pages 281 - 297
NIELSEN PEEGHOLM MBERG RHBUCHARDT O: "Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide", SCIENCE, vol. 254, no. 5037, December 1991 (1991-12-01), pages 1497 - 1500, XP002912953, DOI: 10.1126/science.1962210
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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