Title:
COMPOSITION COMPRISING A RECOMBINANT VIRUS EXPRESSING AN ANTIGEN AND A RECOMBINANT VIRUS EXPRESSING AN IMMUNOSTIMULATORY MOLECULE
Document Type and Number:
WIPO Patent Application WO1996010419
Kind Code:
A3
Abstract:
The present invention relates to a host cell infected using a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Method of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provided using the composition.
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Inventors:
SCHLOM JEFFREY
KANTOR JUDITH
KANTOR JUDITH
Application Number:
PCT/US1995/012624
Publication Date:
May 17, 1996
Filing Date:
October 02, 1995
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
International Classes:
C12N15/09; A61K35/74; A61K35/76; A61K38/00; A61K39/00; A61K39/002; A61K39/02; A61K39/12; A61K39/145; A61K39/193; A61K39/21; A61K39/245; A61K39/275; A61K39/29; A61K39/395; A61K45/00; A61K48/00; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P35/02; A61P37/04; C07K14/705; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N7/01; C12P21/08; (IPC1-7): A61K39/00; A61K45/05
Domestic Patent References:
| WO1991002805A2 | 1991-03-07 | |||
| WO1992019266A1 | 1992-11-12 |
Other References:
BALLOUL, J.M. ET AL., CELLULAR AND MOLECULAR BIOLOGY, vol. 40, pages 49 - 59
RAMSAY, A.J. ET AL., REPRODUCTION FERTILITY AND DEVELOPMENT, vol. 6, 26 September 1994 (1994-09-26), pages 389 - 392
HELLSTRÖM, K.E. ET AL., ANNALS NY ACAD. SCI., vol. 690, pages 24 - 31
KANTOR, J. ET AL., CANCER RESEARCH, vol. 52, pages 6917 - 6925
CHEN, L. ET AL., THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 179, pages 523 - 532
DÖHRING, C. ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 57, pages 754 - 759
HATHCOCK, K.S. ET AL, THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, pages 631 - 640
TOWNSEND, S.E. ET AL., SCIENCE, vol. 259, pages 368 - 370
RAMSAY, A.J. ET AL., REPRODUCTION FERTILITY AND DEVELOPMENT, vol. 6, 26 September 1994 (1994-09-26), pages 389 - 392
HELLSTRÖM, K.E. ET AL., ANNALS NY ACAD. SCI., vol. 690, pages 24 - 31
KANTOR, J. ET AL., CANCER RESEARCH, vol. 52, pages 6917 - 6925
CHEN, L. ET AL., THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 179, pages 523 - 532
DÖHRING, C. ET AL., INTERNATIONAL JOURNAL OF CANCER, vol. 57, pages 754 - 759
HATHCOCK, K.S. ET AL, THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, pages 631 - 640
TOWNSEND, S.E. ET AL., SCIENCE, vol. 259, pages 368 - 370
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