Title:
COMPOSITION CONTAINING OROTIC ACID, AND PROCESS FOR PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/081604
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a process for producing a composition containing orotic acid and having a uric acid content of equal to or lower than a detection limit with high efficiency and at low cost by separating and removing uric acid from a liquid composition containing orotic acid and uric acid. The present invention provides a process for producing a composition containing orotic acid and having a uric acid content of equal to or lower than a detection limit, which comprises a step of bringing active carbon into contact with a liquid composition containing orotic acid and uric acid, a step of bringing the active carbon that has been subjected to the contacting procedure into contact with an alkaline solution to elute orotic acid, and a step of collecting the eluted alkaline solution containing orotic acid.
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Inventors:
NOZAWA HAJIME (JP)
HATTA SHIGEKI (JP)
HATTA SHIGEKI (JP)
Application Number:
PCT/JP2011/078874
Publication Date:
June 21, 2012
Filing Date:
December 14, 2011
Export Citation:
Assignee:
KIRIN HOLDINGS KK (JP)
NOZAWA HAJIME (JP)
HATTA SHIGEKI (JP)
NOZAWA HAJIME (JP)
HATTA SHIGEKI (JP)
International Classes:
C07D239/54; A61K31/513; A61P1/16; A61P3/02; A61P19/06; A61P29/00
Domestic Patent References:
| WO2009069291A1 | 2009-06-04 |
Other References:
ANJA BAUMEISTER ET AL.: "Concentration and purification of orotic acid directly from whey with an expanded bed adsorption system", JOURNAL OF CHROMATOGRAPHY A, vol. 1006, 2003, pages 261 - 265, XP004442196, DOI: doi:10.1016/S0021-9673(03)00945-2
E. N. PAPADAKIS ET AL.: "Application of a microwave-assisted extraction method for the extraction of organic acids from Greek cheeses and sheep milk yoghurt and subsequent analysis by ion-exclusion liquid chromatography", INTERNATIONAL DAIRY JOURNAL, vol. 15, no. 2, 2005, pages 165 - 172, XP004706934, DOI: doi:10.1016/j.idairyj.2004.06.006
A. A. AHMED ET AL.: "Isolation, Quantification, and Biosynthetic Origin of Orotic Acid in Milk", JOURNAL OF DAIRY SCIENCE, vol. 61, no. 1, 1978, pages 39 - 43
E. N. PAPADAKIS ET AL.: "Application of a microwave-assisted extraction method for the extraction of organic acids from Greek cheeses and sheep milk yoghurt and subsequent analysis by ion-exclusion liquid chromatography", INTERNATIONAL DAIRY JOURNAL, vol. 15, no. 2, 2005, pages 165 - 172, XP004706934, DOI: doi:10.1016/j.idairyj.2004.06.006
A. A. AHMED ET AL.: "Isolation, Quantification, and Biosynthetic Origin of Orotic Acid in Milk", JOURNAL OF DAIRY SCIENCE, vol. 61, no. 1, 1978, pages 39 - 43
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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Claims:
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