COMPOSITION CONTAINING C/EBPα-SARNA

Title:

COMPOSITION CONTAINING C/EBPα-SARNA

Document Type and Number:

WIPO Patent Application WO/2023/024230

Kind Code:

A1

Abstract:

Provided is a composition containing C/EBPα‑saRNA targeting a CEBPA transcript, comprising at least one C/EBPα‑saRNA and at least one saRNA or siRNA of a protein bound to C/EBPα. The saRNA is selected from p21‑saRNA. The siRNA is selected from C/EBPβ‑siRNA. Also provided is a use of the composition of the C/EBPα‑saRNA in preparation of medicines.

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Inventors:

ZHAO XIAOYANG (CN)

Application Number:

PCT/CN2021/124412

Publication Date:

March 02, 2023

Filing Date:

October 18, 2021

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Assignee:

ZHAO XIAOYANG (CN)
ANPU INTERNATIONAL MEDICAL TECH SHENZHEN CO LTD (CN)

International Classes:

A61K31/7088; A61K31/713; A61P1/16; A61P35/00

Domestic Patent References:

WO2021021713A1

2021-02-04

Foreign References:

CN112543809A	2021-03-23
CN107075515A	2017-08-18
US20190249176A1	2019-08-15

Other References:

ZHAO, XIAOYANG ET AL.: "Mechanisms involved in the activation of C/EBPα by small activating RNA in hepatocellular carcinoma", ONCOGENE, vol. 38, 14 January 2019 (2019-01-14), XP036847031, DOI: 10.1038/s41388-018-0665-6
VOUTILA, J. ET AL.: "Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer", MOLECULAR THERAPY, vol. 25, no. 12, 31 December 2017 (2017-12-31), XP055439209, DOI: 10.1016/j.ymthe.2017.07.018
LI, SHENGAI: "p21W AF1/CIP1 Gene Upstream Main Transcription Regulatory Sequence Region and Related Function Thereof", JOURNAL OF MEDICAL MOLECULAR BIOLOGY, vol. 23, no. 02, 31 December 2001 (2001-12-31), pages 70 - 74, XP009543781, ISSN: 1672-8009

Attorney, Agent or Firm:

SCIHEAD IP LAW FIRM (CN)

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