Title:
COMPOSITION OF DRUG AND WILD-TYPE CELL-PENETRATING PEPTIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2022/037514
Kind Code:
A1
Abstract:
The present invention belongs to the field of pharmaceutical formulations, and relates to a composition comprising a derivative of a wild-type cell-penetrating peptide penetratin and a drug having positive charge under physiological pH conditions. The derivative of the wild-type cell-penetrating peptide penetratin is a lipophilic derivative designed by using the wild-type cell-penetrating peptide penetratin, and the molecule is positively charged as a whole under physiological pH conditions. Said composition of the present invention, as an ocular drug delivery system, can enable a drug positively charged under physiological pH conditions to be absorbed to the posterior segment of the eye by means of eye dropping, thereby providing a new route for achieving ocular delivery of a drug positively charged under physiological pH conditions.
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Inventors:
WEI GANG (CN)
JIANG KUAN (CN)
LEE BENJAMIN TAK KWONG (CN)
WANG YANFENG (CN)
JIANG KUAN (CN)
LEE BENJAMIN TAK KWONG (CN)
WANG YANFENG (CN)
Application Number:
PCT/CN2021/112687
Publication Date:
February 24, 2022
Filing Date:
August 16, 2021
Export Citation:
Assignee:
ALEPHOSON BIOPHARMACEUTICALS LTD (CN)
UNIV FUDAN (CN)
UNIV FUDAN (CN)
International Classes:
A61P27/02; A61K47/42; C07K7/08
Domestic Patent References:
| WO2019018350A1 | 2019-01-24 |
Foreign References:
| CN108976288A | 2018-12-11 | |||
| CN107638405A | 2018-01-30 | |||
| CN109420178A | 2019-03-05 | |||
| CN108976288A | 2018-12-11 |
Other References:
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JOVCEVSKA IMUYLDERMANS S: "The Therapeutic Potential of Nanobodies", BIODRUGS, vol. 34, 2020, pages 11 - 26, XP055872374, DOI: 10.1007/s40259-019-00392-z
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J CONTROL RELEASE, vol. 118, no. 2, 2007, pages 177 - 84
KENTARO TOMII: "Encyclopedia of Bioinformatics and Computational Biology", vol. 2, 2019, article "Protein Properties", pages: 28 - 33
HOPKINS ESHARMA S: "StatPearls [Internet", 16 June 2019, STATPEARLS PUBLISHING, article "Physiology, Acid Base Balance"
MELVIN E. LASKINEIL A. KURTZMAN: "Acid-base disorders in medicine", DISEASE-A-MONTH, vol. 42, no. 2, 1996, pages 59 - 125, XP027522599
JOVCEVSKA IMUYLDERMANS S: "The Therapeutic Potential of Nanobodies", BIODRUGS, vol. 34, 2020, pages 11 - 26, XP055872374, DOI: 10.1007/s40259-019-00392-z
RUBEL CHAKRAVARTYSHREYA GOELWEIBO CAI: "Nanoantibody: The ''Magic Bullet'' for Molecular Imaging?", THERANOSTICS, vol. 4, no. 4, 2014, pages 386 - 398
INVEST OPHTHALMOL VIS SCI, vol. 58, no. 5, 2017, pages 2578 - 2590
J CONTROL RELEASE, vol. 118, no. 2, 2007, pages 177 - 84
Attorney, Agent or Firm:
TEE&HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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