Title:
COMPOSITION FOR ENHANCING ADRENOMEDULLIN GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2022/102788
Kind Code:
A1
Abstract:
The present invention provides a composition that has an effect of enhancing the gene expression of adrenomedullin. One or more embodiments of the present invention pertain to a composition for enhancing adrenomedullin gene expression, said composition comprising a TRPV1 agonist and a TRPA1 agonist as active ingredients. Examples of the TRPV1 agonist include one or more selected from among capsaicin, 6-shogaol, 6-gingerol and piperine. Examples of the TRPA1 agonist include one or more selected from among allyl isothiocyanate, cinnamaldehyde, diallyl disulfide, ASP7663 and an oxylipin.
Inventors:
NAKANISHI KASUMI (JP)
ASADA KAZUKI (JP)
OHARA TATSUYA (JP)
MUROYAMA KOUTAROU (JP)
ASADA KAZUKI (JP)
OHARA TATSUYA (JP)
MUROYAMA KOUTAROU (JP)
Application Number:
PCT/JP2021/042112
Publication Date:
May 19, 2022
Filing Date:
November 16, 2021
Export Citation:
Assignee:
HOUSE WELLNESS FOODS CORP (JP)
International Classes:
A61K45/00; A61K31/10; A61K31/11; A61K31/12; A61K31/165; A61K31/26; A61K31/4035; A61K31/4525; A61P1/04; A61P9/00; A61P43/00; C07K14/575
Foreign References:
| JP2017513864A | 2017-06-01 |
Other References:
KONO TORU, KANEKO ATSUSHI, OMIYA YUJI, OHBUCHI KATSUYA, OHNO NAGISA, YAMAMOTO MASAHIRO: "Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 304, no. 4, 15 February 2013 (2013-02-15), US , pages G428 - G436, XP055929518, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00356.2012
WATANABE, TATSUO: "Effects of pungent compounds in spice on health", FOOD STYLE 21, vol. 19, no. 7, 2015, pages 32 - 35, XP009536697, ISSN: 1343-9502
WATANABE, TATSUO: "Effects of pungent compounds in spice on health", FOOD STYLE 21, vol. 19, no. 7, 2015, pages 32 - 35, XP009536697, ISSN: 1343-9502
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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