Title:
METHOD OF PRODUCING ASTROCYTES FROM PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2022/102787
Kind Code:
A1
Abstract:
The present invention provides a method of producing astrocytes from pluripotent stem cells, said method comprising a step for expressing NEUROG2 gene in the pluripotent stem cells for less than three days.
Inventors:
INOUE HARUHISA (JP)
KONDO TAKAYUKI (JP)
KONDO TAKAYUKI (JP)
Application Number:
PCT/JP2021/042096
Publication Date:
May 19, 2022
Filing Date:
November 16, 2021
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/071; A61K35/30; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C12N5/10; C12N15/12; C12N15/85; C12N15/87
Domestic Patent References:
| WO2019235576A1 | 2019-12-12 | |||
| WO2014148646A1 | 2014-09-25 |
Other References:
TCHIEU JASON; CALDER ELIZABETH L.; GUTTIKONDA SUDHA R.; GUTZWILLER EVELINE M.; AROMOLARAN KELLY A.; STEINBECK JULIUS A.; GOLDSTEIN: "NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 37, no. 3, 25 February 2019 (2019-02-25), New York, pages 267 - 275, XP036900609, ISSN: 1087-0156, DOI: 10.1038/s41587-019-0035-0
TETSURO YASUI, KINICHI NAKAJIMA: "Effect of oxygen concentration on acquisition of astrocyte differentiation ability of human pluripotent stem cell-derived neural stem / progenitor cells via epigenetics", FOLIA PHARMACOLOGICA JAPONICA, vol. 153, no. 2, 1 January 2019 (2019-01-01), JP , pages 54 - 60, XP009536668, ISSN: 1347-8397, DOI: 10.1254/fpj.153.54
TETSURO YASUI, KINICHI NAKAJIMA: "Effect of oxygen concentration on acquisition of astrocyte differentiation ability of human pluripotent stem cell-derived neural stem / progenitor cells via epigenetics", FOLIA PHARMACOLOGICA JAPONICA, vol. 153, no. 2, 1 January 2019 (2019-01-01), JP , pages 54 - 60, XP009536668, ISSN: 1347-8397, DOI: 10.1254/fpj.153.54
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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