Title:
COMPOSITION FOR IMPROVING JOINT FUNCTION
Document Type and Number:
WIPO Patent Application WO/2022/163323
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a composition for improving joint function, which promotes the proliferation of cartilage cells and inhibits the production of inflammation factors, cartilage matrix degradation factors, pain factors and nerve elongation factors by synovial cells, and, therefore, which is useful for preventing and treating various joint diseases such as osteoarthritis represented by osteoarthritis of the knee and rheumatoid arthritis; and products for improving joint function such as a food or beverage, a feed and a medicine each comprising the aforesaid composition. A composition for improving joint function that comprises cells of a bacterium belonging to the genus Lactobacillus, Lactococcus, Streptococcus or Bifidobacterium or a culture thereof. An agent for improving joint function, a food or beverage for improving joint function, a nutritional composition for improving joint function, a feed for improving joint function or a medicine for improving joint function, each being characterized by comprising the aforesaid composition for improving joint function.
Inventors:
NAKANO AYATAKE (JP)
YASUEDA TAKEHIKO (JP)
SETO YASUYUKI (JP)
YASUEDA TAKEHIKO (JP)
SETO YASUYUKI (JP)
Application Number:
PCT/JP2022/000313
Publication Date:
August 04, 2022
Filing Date:
January 07, 2022
Export Citation:
Assignee:
MEGMILK SNOW BRAND CO LTD (JP)
International Classes:
A61P19/02; A23K10/16; A23L2/52; A23L33/135; A61K35/744; A61K35/745; A61K35/747; C12N1/20; A21D13/45; A23C9/123; A23C9/152; A23C19/09; A23D7/00; A23L9/10; A23L9/20; A23L21/10
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| WO2021112041A1 | 2021-06-10 | |||
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AMDEKAR SARIKA, KUMAR AVNISH, SINGH VINOD: "Transcriptional activity of cytokines induced by oral administration of Lactobacillus casei and Lactobacillus acidophilus in experimental model of arthritis", AIMS MOLECULAR SCIENCE, vol. 4, no. 2, 1 January 2017 (2017-01-01), pages 164 - 174, XP055954970, ISSN: 2372-0301, DOI: 10.3934/molsci.2017.2.164
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ZAMANI BATOL, FARSHBAF SHIMA, GOLKAR HAMID R., BAHMANI FERESHTEH, ASEMI ZATOLLAH: "Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial", BRITISH JOURNAL OF NUTRITION, UK, vol. 117, no. 8, 28 April 2017 (2017-04-28), UK , pages 1095 - 1102, XP055954972, ISSN: 0007-1145, DOI: 10.1017/S000711451700085X
SHEIL B, ET AL.: "IS THE MUCOSAL ROUTE OF ADMINISTRATION ESSENTIAL FOR PROBIOTIC FUNCTION? SUBCUTANEOUS ADMINISTRATION IS ASSOCIATED WITH ATTENUATION OF MURINE COLITIS AND ARTHRITIS", GUT MICROBIOTA, BRITISH MEDICAL ASSOCIATION , LONDON, UK, vol. 53, no. 05, 1 May 2004 (2004-05-01), UK , pages 694 - 700, XP009031213, ISSN: 0017-5749, DOI: 10.1136/gut.2003.027789
ACHI SAJAN CHANDRANGADHAN; TALAHALLI RAMAPRASAD RAVICHANDRA; HALAMI PRAKASH MOTIRAM: "Prophylactic effects of probioticBifidobacteriumspp. in the resolution of inflammation in arthritic rats", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 103, no. 15, 5 June 2019 (2019-06-05), Berlin/Heidelberg, pages 6287 - 6296, XP036830413, ISSN: 0175-7598, DOI: 10.1007/s00253-019-09864-2
HENROTIN YVES, PATRIER STÉPHANE, PRALUS AMANDINE, ROCHE MATHILDE, NIVOLIEZ ADRIEN: "Protective Actions of Oral Administration of Bifidobacterium longum CBi0703 in Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pig Model", CARTILAGE, vol. 13, no. 2_suppl, 1 December 2021 (2021-12-01), pages 1204S - 1213S, XP055954977, ISSN: 1947-6035, DOI: 10.1177/1947603519841674
KAKADIYA, P. ; PATEL, V.: "Anti-rheumatoid activity of cell wall contents of Lactococcus lactis subsp. cremoris.", INTERNATIONAL JOURNAL OF PHARMA AND BIO SCIENCES, vol. 5, no. 4, 1 January 2014 (2014-01-01), IN , pages B-118 - B-127, XP009538667, ISSN: 0975-6299
AMDEKAR SARIKA, KUMAR AVNISH, SINGH VINOD: "Transcriptional activity of cytokines induced by oral administration of Lactobacillus casei and Lactobacillus acidophilus in experimental model of arthritis", AIMS MOLECULAR SCIENCE, vol. 4, no. 2, 1 January 2017 (2017-01-01), pages 164 - 174, XP055954970, ISSN: 2372-0301, DOI: 10.3934/molsci.2017.2.164
SEUNG HOON LEE, JI YE KWON, JOOYEON JHUN, KYUNGAH JUNG, SUNG-HWAN PARK, CHUL WOO YANG, YONGSIN CHO, SEOK JUNG KIM, MI-LA CHO: "Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis", IMMUNOLOGY LETTERS, ELSEVIER BV, NL, vol. 203, 1 November 2018 (2018-11-01), NL , pages 6 - 14, XP055710654, ISSN: 0165-2478, DOI: 10.1016/j.imlet.2018.07.003
JHUN JOOYEON, MIN HONG-KI, NA HYUN SIK, KWON JI YE, RYU JAEYOON, CHO KEUN-HYUNG, CHOI JEONGWON, JUNG KYOUNGAH, LEE SEON-YEONG, KIM: "Combinatmarion treatment with Lactobacillus acidophilus LA-1, vitamin B, and curcumin ameliorates the progression of osteoarthritis by inhibiting the pro-inflammatory mediators", IMMUNOLOGY LETTERS, ELSEVIER BV, NL, vol. 228, 1 December 2020 (2020-12-01), NL , pages 112 - 121, XP055954971, ISSN: 0165-2478, DOI: 10.1016/j.imlet.2020.10.008
ZAMANI BATOL, FARSHBAF SHIMA, GOLKAR HAMID R., BAHMANI FERESHTEH, ASEMI ZATOLLAH: "Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial", BRITISH JOURNAL OF NUTRITION, UK, vol. 117, no. 8, 28 April 2017 (2017-04-28), UK , pages 1095 - 1102, XP055954972, ISSN: 0007-1145, DOI: 10.1017/S000711451700085X
SHEIL B, ET AL.: "IS THE MUCOSAL ROUTE OF ADMINISTRATION ESSENTIAL FOR PROBIOTIC FUNCTION? SUBCUTANEOUS ADMINISTRATION IS ASSOCIATED WITH ATTENUATION OF MURINE COLITIS AND ARTHRITIS", GUT MICROBIOTA, BRITISH MEDICAL ASSOCIATION , LONDON, UK, vol. 53, no. 05, 1 May 2004 (2004-05-01), UK , pages 694 - 700, XP009031213, ISSN: 0017-5749, DOI: 10.1136/gut.2003.027789
ACHI SAJAN CHANDRANGADHAN; TALAHALLI RAMAPRASAD RAVICHANDRA; HALAMI PRAKASH MOTIRAM: "Prophylactic effects of probioticBifidobacteriumspp. in the resolution of inflammation in arthritic rats", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 103, no. 15, 5 June 2019 (2019-06-05), Berlin/Heidelberg, pages 6287 - 6296, XP036830413, ISSN: 0175-7598, DOI: 10.1007/s00253-019-09864-2
HENROTIN YVES, PATRIER STÉPHANE, PRALUS AMANDINE, ROCHE MATHILDE, NIVOLIEZ ADRIEN: "Protective Actions of Oral Administration of Bifidobacterium longum CBi0703 in Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pig Model", CARTILAGE, vol. 13, no. 2_suppl, 1 December 2021 (2021-12-01), pages 1204S - 1213S, XP055954977, ISSN: 1947-6035, DOI: 10.1177/1947603519841674
KAKADIYA, P. ; PATEL, V.: "Anti-rheumatoid activity of cell wall contents of Lactococcus lactis subsp. cremoris.", INTERNATIONAL JOURNAL OF PHARMA AND BIO SCIENCES, vol. 5, no. 4, 1 January 2014 (2014-01-01), IN , pages B-118 - B-127, XP009538667, ISSN: 0975-6299
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
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