Title:
COMPOSITION INHIBITING ACTIVATION OF ADENOSINE RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2022/050230
Kind Code:
A1
Abstract:
A composition for inhibiting the production of IL-22, IL-31 or IFN-kappa, or for treating, ameliorating or preventing diseases caused by abnormal production of IL-22, IL-31 or IFN-kappa, said composition comprising, as an active ingredient, a substance that inhibits the activation of adenosine A2A receptor and/or adenosine A2B receptor.
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Inventors:
KAWANO MASAAKI (JP)
MATSUSHITA SHO (JP)
TAKAGI RIE (JP)
TOKANO MIEKO (JP)
MATSUSHITA SHO (JP)
TAKAGI RIE (JP)
TOKANO MIEKO (JP)
Application Number:
PCT/JP2021/031777
Publication Date:
March 10, 2022
Filing Date:
August 30, 2021
Export Citation:
Assignee:
UNIV SAITAMA MEDICAL (JP)
International Classes:
A61K45/00; A61P43/00; C12Q1/02; C12Q1/44; A61K31/506; A61K31/519; A61K31/52; A61K31/522; A61K31/53; A61K31/5377; A61K31/661; C07D401/04; C07D401/14; C07D403/14; C07D473/06; C07D473/12; C07D473/16; C07D473/32; C07D487/04; C07D487/14; C07D495/04
Domestic Patent References:
| WO2021084791A1 | 2021-05-06 |
Foreign References:
| JP2005516975A | 2005-06-09 | |||
| JP2018510918A | 2018-04-19 | |||
| JP2010535786A | 2010-11-25 | |||
| JP2006519824A | 2006-08-31 | |||
| JP2005513041A | 2005-05-12 | |||
| US20110027295A1 | 2011-02-03 |
Other References:
WEI WEI, DU CHANGSHENG, LV JIE, ZHAO GUIXIAN, LI ZHENXIN, WU ZHIYING, HASKÓ GYÖRGY, XIE XIN: "Blocking A 2B Adenosine Receptor Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis via Inhibition of IL-6 Production and Th17 Differentiation", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 190, no. 1, 1 January 2013 (2013-01-01), US , pages 138 - 146, XP055913644, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1103721
FUJITA HIDEKI: "The role of IL-22 in the pathogenesis of skin diseases", J. CLIN. IMMUNOL, vol. 35, no. 3, 1 January 2012 (2012-01-01), pages 168 - 175, XP055913645
AHMAD, S. F. ET AL.: "Adenosine A2A receptor signaling affects IL -21/ IL -22 cytokines and GATA3/T-bet transcription factor expression in CD 4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism", J. NEUROIMMUNOLOGY, vol. 311, 2017, pages 59 - 67, XP085184846, DOI: 10.1016/j.jneuroim. 2017.08.00 2
ALCHERA, E. ET AL.: "Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity", TRANSLATIONAL RESEARCH, vol. 182, 2017, pages 75 - 87, XP029947175, DOI: 10.1016/j.trsl.2016.11.009
DAI, X. ET AL.: "House dust mite allergen releases IL -31 and IL -33 from epidermal keratinocytes via ATP signaling", J. DERMATOLOGICAL SCIENCE, vol. 84, no. 1, 2016, pages e70 - e71, XP029754193
FUJITA HIDEKI: "The role of IL-22 in the pathogenesis of skin diseases", J. CLIN. IMMUNOL, vol. 35, no. 3, 1 January 2012 (2012-01-01), pages 168 - 175, XP055913645
AHMAD, S. F. ET AL.: "Adenosine A2A receptor signaling affects IL -21/ IL -22 cytokines and GATA3/T-bet transcription factor expression in CD 4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism", J. NEUROIMMUNOLOGY, vol. 311, 2017, pages 59 - 67, XP085184846, DOI: 10.1016/j.jneuroim. 2017.08.00 2
ALCHERA, E. ET AL.: "Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity", TRANSLATIONAL RESEARCH, vol. 182, 2017, pages 75 - 87, XP029947175, DOI: 10.1016/j.trsl.2016.11.009
DAI, X. ET AL.: "House dust mite allergen releases IL -31 and IL -33 from epidermal keratinocytes via ATP signaling", J. DERMATOLOGICAL SCIENCE, vol. 84, no. 1, 2016, pages e70 - e71, XP029754193
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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