Title:
COMPOSITION FOR INHIBITING GROWTH OF CANCER STEM CELLS, CONTAINING CIS-3-HEXENAL
Document Type and Number:
WIPO Patent Application WO/2018/021618
Kind Code:
A1
Abstract:
The present invention relates to: a composition and an aromatic composition, which are for inhibiting the growth of cancer stem cells and contain, as an active ingredient, cis-3-hexenal or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition, food composition, and the like, which are for inhibiting cancer metastasis or for treating or preventing cancer and contain the composition. Cis-3-hexenal of the present invention inhibits the growth of breast and lung cancer cells and inhibits the formation of breast and lung cancer stem cells. In addition, cis-3-hexenal of the present invention has been confirmed to inhibit the expression of self-renewal genes, such as Nanog, C-myc, Oct4, and CD44, which are known to be distinctively expressed in breast cancer stem cells, inhibit the production of IL-6, which is known to be involved in the formation of mammospheres of breast cancer stem cells, and inhibit the STAT3 signaling pathway. Furthermore, cis-3-hexenal has been confirmed to inhibit the production of IL-8, which is known to be involved in the formation of tumorspheres of lung cancer stem cells, and inhibit the NF-κB signaling pathway. Therefore, the compound inhibits the growth of stem cells of cancer such as breast and lung cancer and inhibits the growth of the cancer, thereby being usable in the treatment of cancer such as breast and lung cancer.
Inventors:
LEE DONG-SUN (KR)
KO SANG WOON (KR)
CHOI HACK SUN (KR)
KIM JIHYANG (KR)
KIM SULIM (KR)
JUNG DONG KEE (KR)
KO SANG WOON (KR)
CHOI HACK SUN (KR)
KIM JIHYANG (KR)
KIM SULIM (KR)
JUNG DONG KEE (KR)
Application Number:
PCT/KR2016/011209
Publication Date:
February 01, 2018
Filing Date:
October 06, 2016
Export Citation:
Assignee:
LEE DONG-SUN (KR)
International Classes:
A61K31/11; A24D3/06; A24D3/08; A24D3/14; A61K8/33; A61L9/04; A61Q13/00
Foreign References:
| KR20090114747A | 2009-11-04 | |||
| JP2004182699A | 2004-07-02 | |||
| JP2014155483A | 2014-08-28 | |||
| JP2015165822A | 2015-09-24 |
Other References:
KAKARALA, M. ET AL.: "Targeting Breast Stem Cells with the Cancer Preventive Compounds Curcumin and Piperine", BREAST CANCER RESEARCH AND TREATMENT, vol. 122, 2010, pages 777 - 785, XP019814409
Attorney, Agent or Firm:
KIM, Jin Dong (KR)
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