COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS

Title:

COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS

Document Type and Number:

WIPO Patent Application WO/2022/077549

Kind Code:

A1

Abstract:

Provided are a composition for inducing cell transdifferentiation and a use thereof in inducing the transdifferentiation of non-neuronal cells into neurons. The composition comprises a Myosin inhibitor, an isoxazole compound and/or a derivative thereof. Further provided is a method for inducing the transdifferentiation of non-neuronal cells into neurons, comprising: placing non-neuronal cells in an induction culture solution containing a Myosin inhibitor and culturing same, and then culturing by using a mature culture solution comprising a Myosin inhibitor, an isoxazole compound and/or a derivative thereof until mature neurons are obtained. Also provided is a method for transdifferentiating non-neuronal cells within a subject into neurons, comprising administering to the subject an effective amount of a Myosin inhibitor, an isoxazole compound and/or a derivative thereof.

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Inventors:

LI WEI (CN)
ZHOU QI (CN)
HE ZHENGQUAN (CN)

Application Number:

PCT/CN2020/123227

Publication Date:

April 21, 2022

Filing Date:

October 23, 2020

Export Citation:

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Assignee:

INST ZOOLOGY CAS (CN)
BEIJING INST FOR STEM CELL AND REGENERATIVE MEDICINE (CN)

International Classes:

C12N5/0793; A61K31/4745; A61P25/00

Foreign References:

CN111500538A	2020-08-07
CN111471653A	2020-07-31
CN108531453A	2018-09-14
CN110396500A	2019-11-01
CN103849601A	2014-06-11
CN106337037A	2017-01-18
CN110283788A	2019-09-27

Other References:

XIANG LI, XIAOHAN ZUO, JUNZHAN JING, YANTAO MA, JIAMING WANG, DEFANG LIU, JIALIANG ZHU, XIAOMIN DU, LIANG XIONG, YUANYUAN DU, JUN : "Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons", CELL STEM CELL, ELSEVIER, vol. 17, no. 2, 1 August 2015 (2015-08-01), AMSTERDAM, NL , pages 195 - 203, XP055345517, ISSN: 1934-5909, DOI: 10.1016/j.stem.2015.06.003
BETTIO LUIS E B; PATTEN ANNA R; GIL-MOHAPEL JOANA; O’ROURKE NATASHA F; HANLEY RONAN P; KENNEDY SAMANTHA; GOPALAKRISHNAN KARTHIK; R: "ISX-9 can potentiate cell proliferation and neuronal commitment in the rat dentate gyrus", NEUROSCIENCE, vol. 332, 29 June 2016 (2016-06-29), US , pages 212 - 222, XP029666516, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2016.06.042
D. PETRIK, Y. JIANG, S. G. BIRNBAUM, C. M. POWELL, M.-S. KIM, J. HSIEH, A. J. EISCH: "Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule", THE FASEB JOURNAL, vol. 26, no. 8, 1 August 2012 (2012-08-01), US, pages 3148 - 3162, XP055345542, ISSN: 0892-6638, DOI: 10.1096/fj.11-201426
LEE CHRISTOPHER, ROBINSON MEGHAN, WILLERTH STEPHANIE M.: "Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules", ACS CHEMICAL NEUROSCIENCE, vol. 9, no. 12, 19 December 2018 (2018-12-19), US , pages 3175 - 3185, XP055921853, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00365
See also references of EP 4230731A4

Attorney, Agent or Firm:

BEIJING CAIHE LAW FIRM (CN)

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