Title:
COMPOSITION FOR PREVENTING OR IMPROVING HEPATIC DYSFUNCTION
Document Type and Number:
WIPO Patent Application WO/2023/153483
Kind Code:
A1
Abstract:
This composition for preventing or improving hepatic dysfunction contains glutathione trisulfide or a pharmacologically acceptable salt thereof.
Inventors:
MORITA MASAHIKO (JP)
SAKO NAOKI (JP)
SAKO NAOKI (JP)
Application Number:
PCT/JP2023/004432
Publication Date:
August 17, 2023
Filing Date:
February 09, 2023
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
KIRIN HOLDINGS KK (JP)
KIRIN HOLDINGS KK (JP)
International Classes:
A61K38/08; A23L33/175; A61P1/16; A61P29/00; A61P31/14; A61P31/20
Domestic Patent References:
| WO2017057768A1 | 2017-04-06 |
Other References:
ISKUSNYKH IGOR Y., POPOVA TATYANA N., AGARKOV ALEKSANDER A., PINHEIRO DE CARVALHO MIGUEL Â. A., RJEVSKIY STANISLAV G.: "Expression of Glutathione Peroxidase and Glutathione Reductase and Level of Free Radical Processes under Toxic Hepatitis in Rats", JOURNAL OF TOXICOLOGY, HINDAWI PUBLISHING CORPORATION, US, vol. 2013, 1 January 2013 (2013-01-01), US , pages 1 - 9, XP093082831, ISSN: 1687-8191, DOI: 10.1155/2013/870628
T. IDA, ET AL: "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 21, 27 May 2014 (2014-05-27), pages 7606 - 7611, XP055443522, ISSN: 0027-8424, DOI: 10.1073/pnas.1321232111
HIROSHI KUNIKATA, IDA TOMOAKI, SATO KOTA, AIZAWA NAOKO, SAWA TOMOHIRO, TAWARAYAMA HIROSHI, MURAYAMA NAMIE, FUJII SHIGEMOTO, AKAIKE: "Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors", SCIENTIFIC REPORTS, vol. 7, no. 1, 7 February 2017 (2017-02-07), XP055586796, DOI: 10.1038/srep41984
HINO SHO, SATOMI NEMOTO, NAOKI ONIZAWA, NORITAKA ADACHI, HIROYUKI SHIRATANI: "Research on technology to improve reproductive performance by improving liver function using glutathione in dairy cattle", IBARAKI PREFECTURAL LIVESTOCK CENTER RESEARCH REPORT (IBARAKI LIVESTOCK CENTER RESEARCH REPORT), vol. 50, 1 February 2018 (2018-02-01), XP093082835
DAO NAM V., ERCOLE FRANCESCA, KAMINSKAS LISA M., DAVIS THOMAS P., SLOAN ERICA K., WHITTAKER MICHAEL R., QUINN JOHN F.: "Trisulfide-Bearing PEG Brush Polymers Donate Hydrogen Sulfide and Ameliorate Cellular Oxidative Stress", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 12, 14 December 2020 (2020-12-14), US , pages 5292 - 5305, XP093082839, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.0c01347
T. IDA, ET AL: "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 21, 27 May 2014 (2014-05-27), pages 7606 - 7611, XP055443522, ISSN: 0027-8424, DOI: 10.1073/pnas.1321232111
HIROSHI KUNIKATA, IDA TOMOAKI, SATO KOTA, AIZAWA NAOKO, SAWA TOMOHIRO, TAWARAYAMA HIROSHI, MURAYAMA NAMIE, FUJII SHIGEMOTO, AKAIKE: "Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors", SCIENTIFIC REPORTS, vol. 7, no. 1, 7 February 2017 (2017-02-07), XP055586796, DOI: 10.1038/srep41984
HINO SHO, SATOMI NEMOTO, NAOKI ONIZAWA, NORITAKA ADACHI, HIROYUKI SHIRATANI: "Research on technology to improve reproductive performance by improving liver function using glutathione in dairy cattle", IBARAKI PREFECTURAL LIVESTOCK CENTER RESEARCH REPORT (IBARAKI LIVESTOCK CENTER RESEARCH REPORT), vol. 50, 1 February 2018 (2018-02-01), XP093082835
DAO NAM V., ERCOLE FRANCESCA, KAMINSKAS LISA M., DAVIS THOMAS P., SLOAN ERICA K., WHITTAKER MICHAEL R., QUINN JOHN F.: "Trisulfide-Bearing PEG Brush Polymers Donate Hydrogen Sulfide and Ameliorate Cellular Oxidative Stress", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 12, 14 December 2020 (2020-12-14), US , pages 5292 - 5305, XP093082839, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.0c01347
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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