Title:
COMPOSITION FOR PREVENTING OR TREATING AUTOINFLAMMATORY DISEASES, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/096261
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for treating or preventing autoinflammatory diseases, comprising, as an active ingredient, TLR inhibitor peptide 1 (TIP-1) or MAL/MyD88 inhibitory peptide 2 (MIP-2) or a polynucleotide(s) encoding same. It has been identified that the peptides inhibit inflammation in animal models with autoinflammatory diseases and can alleviate clinical symptoms, and thus the present invention can be used as a treatment agent and in a treatment method for autoinflammatory diseases.
Inventors:
KIM HYOUN AH (KR)
CHOI SANGDUN (KR)
AHN MIHYUN (KR)
CHOI YANG-SEON (KR)
CHOI SANGDUN (KR)
AHN MIHYUN (KR)
CHOI YANG-SEON (KR)
Application Number:
PCT/KR2023/011093
Publication Date:
May 10, 2024
Filing Date:
July 31, 2023
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K38/16; A23L33/18; A61K38/00; A61P19/02; A61P29/00
Domestic Patent References:
| WO2018203613A1 | 2018-11-08 |
Foreign References:
| US11047012B2 | 2021-06-29 |
Other References:
MATHIEU GERFAUD-VALENTIN: "Adult-onset Still's disease", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 13, no. 7, 1 July 2014 (2014-07-01), NL , pages 708 - 722, XP093167347, ISSN: 1568-9972, DOI: 10.1016/j.autrev.2014.01.058
WOOK-YOUNG BAEK: "Toll-like Receptor Signaling Inhibitory Peptide Improves Inflammation in Animal Model and Human Systemic Lupus Erythematosus", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 22, no. 23, 1 December 2021 (2021-12-01), Basel, CH , pages 12764, XP093167353, ISSN: 1661-6596, DOI: 10.3390/ijms222312764
M. H. AHN: "POS0235 ANTI-INFLAMMATORY EFFECTS OF TIP-1 AND MIP-2 TREATMENT THROUGH TLRS BLOCKADE IN AOSD ANIMAL MODEL", ANNALS OF THE RHEUMATIC DISEASES, BMJ PUBLISHING GROUP LTD AND EUROPEAN LEAGUE AGAINST RHEUMATISM, vol. 82, 1 June 2023 (2023-06-01), pages 350, XP093167358, DOI: 10.1136/annrheumdis-2023-eular.1757
WOOK-YOUNG BAEK: "Toll-like Receptor Signaling Inhibitory Peptide Improves Inflammation in Animal Model and Human Systemic Lupus Erythematosus", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 22, no. 23, 1 December 2021 (2021-12-01), Basel, CH , pages 12764, XP093167353, ISSN: 1661-6596, DOI: 10.3390/ijms222312764
M. H. AHN: "POS0235 ANTI-INFLAMMATORY EFFECTS OF TIP-1 AND MIP-2 TREATMENT THROUGH TLRS BLOCKADE IN AOSD ANIMAL MODEL", ANNALS OF THE RHEUMATIC DISEASES, BMJ PUBLISHING GROUP LTD AND EUROPEAN LEAGUE AGAINST RHEUMATISM, vol. 82, 1 June 2023 (2023-06-01), pages 350, XP093167358, DOI: 10.1136/annrheumdis-2023-eular.1757
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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