COMPOSITION FOR PREVENTING OR TREATING CELLULAR SENESCENCE-ASSOCIATED DISEASES, CONTAINING HOMOHARRINGTONINE AS ACTIVE INGREDIENT

Title:

COMPOSITION FOR PREVENTING OR TREATING CELLULAR SENESCENCE-ASSOCIATED DISEASES, CONTAINING HOMOHARRINGTONINE AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2020/122391

Kind Code:

A1

Abstract:

The present invention relates to a composition for preventing or treating cellular senescence-associated diseases, containing homoharringtonine as an active ingredient. It is ascertained that a composition containing homoharringtonine as an active ingredient exhibits senolytic effects of selectively killing senescence-induced fibroblasts and renal tubular cells, whereas the composition shows senomorphic effects of restoring cell function and morphology in senescence-induced vascular endothelial cells, epidermal melanocytes and retinal pigment epithelial cells, and thus homoharringtonine can effectively prevent or treat senile eye diseases, tissue fibrosis diseases, atherosclerosis, osteoarthritis, degenerative brain diseases, chronic skin damage, obesity and diabetes, which are caused by cellular senescence, by acting differently depending on the type of cells, and can be provided as a composition for skin whitening and lifespan extension.

Inventors:

KIM JAE-RYONG (KR)
KIM EOK-CHEON (KR)
JUNG KYONG-JIN (KR)
BIN BUM-HO (KR)
SON YOU LIM (KR)

Application Number:

PCT/KR2019/013371

Publication Date:

June 18, 2020

Filing Date:

October 11, 2019

Export Citation:

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Assignee:

UNIV YEUNGNAM RES COOPERATION FOUNDATION (KR)

International Classes:

A61K31/55; A61K8/49; A61P9/10; A61P19/00; A61P27/02; A61P39/06; A61Q19/02

Foreign References:

US20100278784A1	2010-11-04
KR101461775B1	2014-11-13
CN1511531A	2004-07-14
KR20090130129A	2009-12-17
KR20160017603A	2016-02-16

Other References:

LI, X. ET AL.: "Homoharringtonine prevents surgery-induced epidural fibrosis through endoplasmic reticulum stress signaling pathway", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 815, 2017, pages 437 - 445, XP085245809, DOI: 10.1016/j.ejphar.2017.09.027

Attorney, Agent or Firm:

TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)

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