Title:
COMPOSITION FOR PREVENTING OR TREATING CELLULAR SENESCENCE-RELATED DISEASES COMPRISING ZOTAROLIMUS AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2020/122392
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating a cellular senescence-related disease, comprising zotarolimus as an active ingredient. More specifically, by having confirmed that zotarolimus exhibits a senomorphic effect that recovers the function and morphology of aged fibroblasts, umbilical vascular endothelial cells, renal tubular cells, and retinal pigment epithelial cells, and that, through the senomorphic effect, zotarolimus exhibits the effect of improving tissue fibrosis induced by cellular senescence, a composition including the zotarolimus as an active ingredient can be provided as a composition for treating a cellular senescence-related disease.
Inventors:
KIM JAE-RYONG (KR)
KIM EOK-CHEON (KR)
JUNG KYONG-JIN (KR)
SON YOU LIM (KR)
KIM EOK-CHEON (KR)
JUNG KYONG-JIN (KR)
SON YOU LIM (KR)
Application Number:
PCT/KR2019/013372
Publication Date:
June 18, 2020
Filing Date:
October 11, 2019
Export Citation:
Assignee:
UNIV YEUNGNAM RES COOPERATION FOUNDATION (KR)
International Classes:
A61K31/436; A61P3/04; A61P3/10; A61P19/00; A61P25/28; A61P39/06
Domestic Patent References:
| WO2008022256A2 | 2008-02-21 | |||
| WO2011056961A2 | 2011-05-12 |
Foreign References:
| KR20120061081A | 2012-06-12 | |||
| KR20180081501A | 2018-07-16 | |||
| KR101425303B1 | 2014-07-31 |
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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