Title:
COMPOSITION FOR PREVENTING OR TREATING FATTY LIVER DISEASE, COMPRISING, AS ACTIVE INGREDIENT, ENTEROCOCCUS FAECALIS, CULTURE SOLUTION THEREOF OR DEAD CELLS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/153903
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating fatty liver disease, comprising Enterococcus faecalis as an active ingredient. Particularly, it has been identified that dead cells of Enterococcus faecalis EF-2001 prevent fatty liver disease and liver damage in experimental animals in which fatty liver disease is induced by high-fat feeding, reduce TG lipid accumulation, inhibit triglyceride droplet generation, increase lipase enzyme protein expression, induce activation of lipase enzymes such as ATGL and MGL, and increase AMPK phosphorylation so as to inhibit the SREBP-1c signaling pathway, and thus the Enterococcus faecalis, a culture solution thereof or dead cells thereof can be very effectively used as a pharmaceutical composition for preventing or treating fatty liver disease.
Inventors:
KIM TACK JOONG (KR)
LEE JIN HO (KR)
LEE JIN HO (KR)
Application Number:
PCT/KR2023/002085
Publication Date:
August 17, 2023
Filing Date:
February 13, 2023
Export Citation:
Assignee:
UNIV INDUSTRY FOUNDATION YONSEI UNIV WONJU CAMPUS (KR)
International Classes:
A61K35/744; A23L33/135; A61K8/99; A61P1/16; A61P35/00; A61Q19/00
Foreign References:
| KR101873193B1 | 2018-07-02 | |||
| CN113164530A | 2021-07-23 | |||
| CN104415062A | 2015-03-18 | |||
| KR101508586B1 | 2015-04-08 | |||
| KR20210075916A | 2021-06-23 |
Attorney, Agent or Firm:
KIM, Bo Jung (KR)
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