Title:
COMPOSITION FOR PREVENTING OR TREATING PULMONARY FIBROSIS INCLUDING EXOSOME EXTRACTED FROM ADIPOSE-DERIVED STEM CELL AS ACTIVE COMPONENT
Document Type and Number:
WIPO Patent Application WO/2018/026203
Kind Code:
A1
Abstract:
The present invention relates to: a composition, which is for preventing or treating pulmonary fibrosis and includes an exosome extracted from an adipose-derived stem cell as an active component; a use of the exosome in the preparation of a pharmaceutical for preventing or treating pulmonary fibrosis; and a pulmonary fibrosis treatment method including a step for administering a subject with a pharmaceutical composition including the exosome as an active component. An exosome extracted from an adipose-derived stem cell according to the present invention includes growth factors, such as HGF (hepatocyte growth factor) and IL-10, related to pulmonary fibrosis treatment, and can significantly reduce the fibrotic region in pulmonary fibrosis-induced test animal models, and thus, can be usefully used in the prevention or treatment of pulmonary fibrosis. Moreover, in a pulmonary fibrosis treatment using an exosome according to the present invention, there is little concern of side effects from steroid-based drugs and antioxidants used in typical pulmonary fibrosis treatments occuring, and exosomes can be naturally transported to the lungs through injection- or ingestion-based administration, without surgical treatment, and thus, pulmonary fibrosis can be treated simply and economically.
Inventors:
CHO YONG WOO (KR)
CHOI JI SUK (KR)
YEOM SEUNG HO (KR)
JUNG YOUN JAE (KR)
CHOI JI SUK (KR)
YEOM SEUNG HO (KR)
JUNG YOUN JAE (KR)
Application Number:
PCT/KR2017/008383
Publication Date:
February 08, 2018
Filing Date:
August 03, 2017
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
A61K35/28; A61K9/00
Domestic Patent References:
| WO2015088288A1 | 2015-06-18 |
Foreign References:
| CN104666344A | 2015-06-03 | |||
| US20150190429A1 | 2015-07-09 | |||
| KR20140024310A | 2014-02-28 | |||
| KR100837167B1 | 2008-06-11 | |||
| KR20090122415A | 2009-11-30 |
Other References:
JIANG, H. ET AL.: "Effect of Transplanted Adipose-derived Stem Cells in Mice Exhibiting Idiopathic Pulmonary Fibrosis", MOLECULAR MEDICINE REPORTS, vol. 12, no. 4, 2015, pages 5933 - 5938, XP055582892, DOI: 10.3892/mmr.2015.4178
REDDY, M. ET AL.: "Human Adipose-derived Mesenchymal Stem Cells Attenuate Early Stage of Bleomycin Induced Pulmonary Fibrosis: Comparison with Pirfenidone", INTERNATIONAL JOURNAL OF STEM CELIS, vol. 9, no. 2, 30 November 2016 (2016-11-30), pages 192 - 206, XP05558289
G RAPOSO ET AL., J. CELL BIOL., vol. 200, no. 4, 2013, pages 373 - 383
TUBERCULOSIS AND RESPIRATORY DISEASES, vol. 54, no. 2, February 2003 (2003-02-01), pages 1 - 12
EXP HEMATOL., vol. 30, 2002, pages 67 - 73
See also references of EP 3494977A4
REDDY, M. ET AL.: "Human Adipose-derived Mesenchymal Stem Cells Attenuate Early Stage of Bleomycin Induced Pulmonary Fibrosis: Comparison with Pirfenidone", INTERNATIONAL JOURNAL OF STEM CELIS, vol. 9, no. 2, 30 November 2016 (2016-11-30), pages 192 - 206, XP05558289
G RAPOSO ET AL., J. CELL BIOL., vol. 200, no. 4, 2013, pages 373 - 383
TUBERCULOSIS AND RESPIRATORY DISEASES, vol. 54, no. 2, February 2003 (2003-02-01), pages 1 - 12
EXP HEMATOL., vol. 30, 2002, pages 67 - 73
See also references of EP 3494977A4
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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