Title:
METHOD FOR PREPARING SUSTAINED-RELEASE OXYGEN OMISSION TYPE IN SITU CROSS-LINKED HYDROGEL USING CALCIUM PEROXIDE AND BIOMEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/026204
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a sustained-release oxygen omission type in situ cross-linked hydrogel using calcium peroxide. The novel form of oxygen omission type in situ cross-linked hydrogel thus prepared is characterized in that the hydrogel is formed by inducing disulfide bonds on a polymer main chain having thiol reactive groups by oxygen generated from the decomposition of calcium peroxide and the oxygen generated in the hydrogel is emitted in a sustained-release type. In addition, the present invention can solve the restrictions of an existing oxygen delivery system, can produce a sustained-release oxygen emission type in situ cross-linked hydrogel through a simple and prompt method, and further can easily control physical/chemical/biological characteristics of the hydrogel according to the preparation conditions.
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Inventors:
PARK KYUNG MIN (KR)
PARK KI DONG (KR)
PARK SU JIN (KR)
PARK KI DONG (KR)
PARK SU JIN (KR)
Application Number:
PCT/KR2017/008386
Publication Date:
February 08, 2018
Filing Date:
August 03, 2017
Export Citation:
Assignee:
UNIV INCHEON IND ACAD COOP (KR)
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
C08J3/075; A61L24/10; A61L26/00; C08J3/24; C08K3/20; C08L3/00; C08L5/00; C08L71/02; C08L89/06; C08L101/00
Foreign References:
| KR20110056630A | 2011-05-31 | |||
| KR20110025530A | 2011-03-10 |
Other References:
VLIERBERGHE, SANDRA VAN ET AL.: "Reversible Gelatin-based Hydrogels: Finetuning of Material Properties", EUROPEAN POLYMER JOURNAL, vol. 47, 24 February 2011 (2011-02-24), pages 1039 - 1047, XP028191261
CAMCI-UNAL, GULDEN ET AL.: "Oxygen-releasing Biomaterials for Tissue Engineering", POLYMER INTERNATIONAL, vol. 62, 3 April 2013 (2013-04-03), pages 843 - 848, XP055461623
GYARMATI, BENJAMIN ET AL.: "Reversible Disulphide Formation in Polymer Networks: A Versatile Functional Group from Synthesis to Applications", EUROPEAN POLYMER JOURNAL, vol. 49, no. 6, 25 March 2013 (2013-03-25), pages 1268 - 1286, XP028562667
CAMCI-UNAL, GULDEN ET AL.: "Oxygen-releasing Biomaterials for Tissue Engineering", POLYMER INTERNATIONAL, vol. 62, 3 April 2013 (2013-04-03), pages 843 - 848, XP055461623
GYARMATI, BENJAMIN ET AL.: "Reversible Disulphide Formation in Polymer Networks: A Versatile Functional Group from Synthesis to Applications", EUROPEAN POLYMER JOURNAL, vol. 49, no. 6, 25 March 2013 (2013-03-25), pages 1268 - 1286, XP028562667
Attorney, Agent or Firm:
CHA, Joon Yong (KR)
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