Title:
COMPOSITION FOR PREVENTING OR TREATING SARS-COV-2, COMPRISING PEGYLATED ALBUMIN-BOUND STEROIDAL GINSENOSIDE DERIVATIVE NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2022/092389
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating SARS-CoV-2, comprising PEGylated albumin-bound steroidal ginsenoside derivative nanoparticles, the composition being capable of reducing steroid side effects by an acute immunosuppressive effect and removing endotoxins, such as a histone and cytokine, in an infectious disease, thereby controlling organ damage and blood clotting mechanisms associated with cytokine release syndrome or a cytokine storm and thus being capable of playing an important role in improving morbidity and mortality rates prior to the development of an antiviral agent in the current SARS-CoV-2 pandemic situation.
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Inventors:
SONG GYU YONG (KR)
LEE JAE YOUNG (KR)
AHN BYUNG HEE (KR)
LEE JEE HYUN (KR)
LEE JAE YOUNG (KR)
AHN BYUNG HEE (KR)
LEE JEE HYUN (KR)
Application Number:
PCT/KR2020/016008
Publication Date:
May 05, 2022
Filing Date:
November 13, 2020
Export Citation:
Assignee:
AREZ CO LTD (KR)
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIV (KR)
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIV (KR)
International Classes:
A61K47/69; A61K31/704; A61K47/10; A61K47/64; A61P31/14
Domestic Patent References:
| WO2019212203A1 | 2019-11-07 |
Other References:
LEE JUNG EUN, KIM MYUNG GOO, JANG YEON LIM, LEE MIN SANG, KIM NAK WON, YIN YUE, LEE JONG HAN, LIM SU YEON, PARK JI WON, KIM JAEYUN: "Self-assembled PEGylated albumin nanoparticles (SPAN) as a platform for cancer chemotherapy and imaging", DRUG DELIVERY, ACADEMIC PRESS, ORLANDO, FL., US, vol. 25, no. 1, 1 January 2018 (2018-01-01), US , pages 1570 - 1578, XP055926406, ISSN: 1071-7544, DOI: 10.1080/10717544.2018.1489430
HUANG YU-FENG; BAI CHEN; HE FAN; XIE YING; ZHOU HUA: "Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 158, 21 May 2020 (2020-05-21), AMSTERDAM, NL, XP086195720, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2020.104939
LEE WONHWA, KU SAE-KWANG, KIM JI-EUN, CHO SOO-HYUN, SONG GYU-YONG, BAE JONG-SUP: "Inhibitory effects of protopanaxatriol type ginsenoside fraction (Rgx365) on particulate matter-induced pulmonary injury", JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART A, TAYLOR & FRANCIS,, US, vol. 82, no. 5, 4 March 2019 (2019-03-04), US , pages 338 - 350, XP055778212, ISSN: 1528-7394, DOI: 10.1080/15287394.2019.1596183
KOUCHAKZADEH HASAN, SHOJAOSADATI SEYED ABBAS, MAGHSOUDI AMIR, VASHEGHANI FARAHANI EBRAHIM: "Optimization of PEGylation Conditions for BSA Nanoparticles Using Response Surface Methodology", AAPS PHARMSCITECH, SPRINGER INTERNATIONAL PUBLISHING, vol. 11, no. 3, 1 September 2010 (2010-09-01), pages 1206 - 1211, XP055926291, DOI: 10.1208/s12249-010-9487-8
HUANG YU-FENG; BAI CHEN; HE FAN; XIE YING; ZHOU HUA: "Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 158, 21 May 2020 (2020-05-21), AMSTERDAM, NL, XP086195720, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2020.104939
LEE WONHWA, KU SAE-KWANG, KIM JI-EUN, CHO SOO-HYUN, SONG GYU-YONG, BAE JONG-SUP: "Inhibitory effects of protopanaxatriol type ginsenoside fraction (Rgx365) on particulate matter-induced pulmonary injury", JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. PART A, TAYLOR & FRANCIS,, US, vol. 82, no. 5, 4 March 2019 (2019-03-04), US , pages 338 - 350, XP055778212, ISSN: 1528-7394, DOI: 10.1080/15287394.2019.1596183
KOUCHAKZADEH HASAN, SHOJAOSADATI SEYED ABBAS, MAGHSOUDI AMIR, VASHEGHANI FARAHANI EBRAHIM: "Optimization of PEGylation Conditions for BSA Nanoparticles Using Response Surface Methodology", AAPS PHARMSCITECH, SPRINGER INTERNATIONAL PUBLISHING, vol. 11, no. 3, 1 September 2010 (2010-09-01), pages 1206 - 1211, XP055926291, DOI: 10.1208/s12249-010-9487-8
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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