Title:
COMPOSITION FOR PRODUCING HYDROXYFATTY ACIDS, HEPOXILINS, OR TRIOXILINS
Document Type and Number:
WIPO Patent Application WO/2018/212624
Kind Code:
A1
Abstract:
The present invention relates to a 11-lipoxygenase consisting of the amino acid sequence represented by SEQ ID NO: 1; or a composition for producing 11-hydroxyfatty acid, hepoxilin D3, or trioxilin D3, comprising the 11-lipoxygenase and an epoxide hydrolase consisting of the amino acid sequence represented by SEQ ID NO: 2; and a method for producing 11-hydroxyfatty acid, hepoxilin D3, or trioxilin D3, using the same composition. In addition, the present invention relates to a 12-lipoxygenase consisting of the amino acid sequence represented by SEQ ID NO: 5; or a composition for producing 12-hydroxyfatty acid, hepoxilin B, or trioxilin B, comprising the 12-lipoxygenase and an epoxide hydrolase consisting of the amino acid sequence represented by SEQ ID NO: 2; and a method for producing 12-hydroxyfatty acid, hepoxilin B, or trioxilin B, using the same composition.
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Inventors:
OH DEOK KUN (KR)
AN JUNG UNG (KR)
AN JUNG UNG (KR)
Application Number:
PCT/KR2018/005730
Publication Date:
November 22, 2018
Filing Date:
May 18, 2018
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
International Classes:
C12P7/64; C07C59/105; C07D303/04; C12N9/02; C12N9/14; C12P17/02
Other References:
MORTIMER, M.: "Identification and characterization of an arachidonate 11R-lipoxygenase", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 445, no. 1, 2006, pages 147 - 155, XP024942962, DOI: doi:10.1016/j.abb.2005.10.023
DATABASE Protein 16 May 2013 (2013-05-16), "lipoxygenase [Myxococcus xanthus]", XP055612750, retrieved from NCBI Database accession no. WP_011551853.1
DATABASE Protein 14 May 2017 (2017-05-14), "alpha/beta hydrolase [Myxococcus xanthus]", XP055612754, retrieved from NCBI Database accession no. WP 011551755.1
ABIAN, J.: "Gas chromatographic/mass spectrometric analysis of high-performance liquid chromatographic-fractions reflecting arachidonic acid metabolism in mouse peritoneal macrophages", BIOLOGICAL MASS SPECTROMETRY, vol. 21, no. 2, 1992, pages 69 - 79, DOI: 10.1002/bms.1200210203
INOUYE, M.: "Formation of 9-hydroxy linoleic acid as a product of phospholipid peroxidation in diabetic erythrocyte membranes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1438, no. 2, 1999, pages 204 - 212, XP004277147, DOI: doi:10.1016/S1388-1981(99)00052-9
DATABASE PubChem COMPOUND 13 January 2006 (2006-01-13), "PubChem COMPOUND CID5283015 -C18H32O4", XP055612758, retrieved from NCBI Database accession no. CID5283015
GAO, J.-M. ET AL: "A new trihydroxy fatty acid from the ascomycete, chinese truffle tuber indicum", LIPIDS, vol. 36, no. 12, December 2001 (2001-12-01), pages 1365 - 1370, XP055612760
BARYLA, A. ET AL: "Evaluation of lipid peroxidation as a toxicity bioassay for plants exposed to copper", ENVIRONMENTAL POLLUTION, vol. 109, no. 1, 2000, pages 131 - 135, XP055612761
DEREWLANY, L. 0.: "Hepoxilin A, hydroxyepoxide metabolite of arachidonic acid, stimulates transport of 45Ca across the guinea pig visceral yolk sac", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 62, no. 12, 1984, pages 1466 - 1469
PACE-ASCIAK, C. R.: "Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(s)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid", PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, vol. 22, no. 1, 9 January 1986 (1986-01-09), pages 1 - 9, XP026327705
REYNAUD, D.: "Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1346, no. 3, 1997, pages 305 - 316, XP055612764
DATABASE Protein 22 October 2016 (2016-10-22), "Lipoxygenase [Myxococcus xanthus]", XP055612767, retrieved from NCBI Database accession no. SDY21018.1
SONG, W.-C. ET AL: "Identification of novel hydroxy fatty acids in the barnacle Balanus balanoides", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1047, no. 3, 1990, pages 239 - 246, XP023366787
DATABASE Protein 16 May 2013 (2013-05-16), "lipoxygenase [Myxococcus xanthus]", XP055612750, retrieved from NCBI Database accession no. WP_011551853.1
DATABASE Protein 14 May 2017 (2017-05-14), "alpha/beta hydrolase [Myxococcus xanthus]", XP055612754, retrieved from NCBI Database accession no. WP 011551755.1
ABIAN, J.: "Gas chromatographic/mass spectrometric analysis of high-performance liquid chromatographic-fractions reflecting arachidonic acid metabolism in mouse peritoneal macrophages", BIOLOGICAL MASS SPECTROMETRY, vol. 21, no. 2, 1992, pages 69 - 79, DOI: 10.1002/bms.1200210203
INOUYE, M.: "Formation of 9-hydroxy linoleic acid as a product of phospholipid peroxidation in diabetic erythrocyte membranes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1438, no. 2, 1999, pages 204 - 212, XP004277147, DOI: doi:10.1016/S1388-1981(99)00052-9
DATABASE PubChem COMPOUND 13 January 2006 (2006-01-13), "PubChem COMPOUND CID5283015 -C18H32O4", XP055612758, retrieved from NCBI Database accession no. CID5283015
GAO, J.-M. ET AL: "A new trihydroxy fatty acid from the ascomycete, chinese truffle tuber indicum", LIPIDS, vol. 36, no. 12, December 2001 (2001-12-01), pages 1365 - 1370, XP055612760
BARYLA, A. ET AL: "Evaluation of lipid peroxidation as a toxicity bioassay for plants exposed to copper", ENVIRONMENTAL POLLUTION, vol. 109, no. 1, 2000, pages 131 - 135, XP055612761
DEREWLANY, L. 0.: "Hepoxilin A, hydroxyepoxide metabolite of arachidonic acid, stimulates transport of 45Ca across the guinea pig visceral yolk sac", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 62, no. 12, 1984, pages 1466 - 1469
PACE-ASCIAK, C. R.: "Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(s)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid", PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, vol. 22, no. 1, 9 January 1986 (1986-01-09), pages 1 - 9, XP026327705
REYNAUD, D.: "Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1346, no. 3, 1997, pages 305 - 316, XP055612764
DATABASE Protein 22 October 2016 (2016-10-22), "Lipoxygenase [Myxococcus xanthus]", XP055612767, retrieved from NCBI Database accession no. SDY21018.1
SONG, W.-C. ET AL: "Identification of novel hydroxy fatty acids in the barnacle Balanus balanoides", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1047, no. 3, 1990, pages 239 - 246, XP023366787
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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