Title:
COMPOSITION FOR REGENERATING PULP-DENTIN COMPLEX, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2023/214791
Kind Code:
A1
Abstract:
The present invention relates to a composition for regenerating a pulp-dentin complex, and a method for producing same. Dental pulp stem cells cultured in the presence of garcinol can promote dentin formation by inhibiting bone differentiation and inducing differentiation into odontoblasts, and can be used to regenerate the pulp-dentin complex. In addition, it is possible to further increase the effect of promoting the dentin formation by 3D culturing dental pulp stem cells in the presence of garcinol.
Inventors:
KIM EUI SEONG (KR)
KIM SUN IL (KR)
LEE SUK JOON (KR)
KIM UK SEONG (KR)
JANG SUN MI (KR)
KIM SUN IL (KR)
LEE SUK JOON (KR)
KIM UK SEONG (KR)
JANG SUN MI (KR)
Application Number:
PCT/KR2023/006029
Publication Date:
November 09, 2023
Filing Date:
May 03, 2023
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K35/32; A61K35/30; A61K35/44; A61P1/02; C12N5/0775; C12N5/0793
Foreign References:
| KR20140021142A | 2014-02-20 | |||
| KR20180101228A | 2018-09-12 |
Other References:
GU SHENSHENG, LIANG JINGPING, WANG JIA, LIU BIN: "Histone acetylation regulates osteodifferentiation of hDPSCs via DSPP", FRONTIERS IN BIOSCIENCE, vol. 18, 1 June 2013 (2013-06-01), pages 1072 - 1079, XP093105668
BAYARSAIHAN DASHZEVEG: "Deciphering the Epigenetic Code in Embryonic and Dental Pulp Stem Cells", THE YALE JOURNAL OF BIOLOGY AND MEDICINE, YALE JOURNAL OF BIOLOGY AND MEDICINE, US, vol. 89, no. 4, 1 December 2016 (2016-12-01), US , pages 539 - 563, XP093105669, ISSN: 0044-0086
WANG TONG, LIU HUIJUAN, NING YANYANG, XU QIONG: "The Histone Acetyltransferase p300 Regulates the Expression of Pluripotency Factors and Odontogenic Differentiation of Human Dental Pulp Cells", PLOS ONE, vol. 9, no. 7, 9 July 2014 (2014-07-09), pages e102117, XP093105670, DOI: 10.1371/journal.pone.0102117
BAYARSAIHAN DASHZEVEG: "Deciphering the Epigenetic Code in Embryonic and Dental Pulp Stem Cells", THE YALE JOURNAL OF BIOLOGY AND MEDICINE, YALE JOURNAL OF BIOLOGY AND MEDICINE, US, vol. 89, no. 4, 1 December 2016 (2016-12-01), US , pages 539 - 563, XP093105669, ISSN: 0044-0086
WANG TONG, LIU HUIJUAN, NING YANYANG, XU QIONG: "The Histone Acetyltransferase p300 Regulates the Expression of Pluripotency Factors and Odontogenic Differentiation of Human Dental Pulp Cells", PLOS ONE, vol. 9, no. 7, 9 July 2014 (2014-07-09), pages e102117, XP093105670, DOI: 10.1371/journal.pone.0102117
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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