COMPOSITIONS COMPRISING D-CHIRO INOSITOL AND SULFONYLUREAS AND METHODS OF TREATMENT THEREOF

WIPO Patent Application WO2002094744

A3

The present invention provides compositions comprising therapeutically effective amounts of D-chiro-inositol and sulfonylureas. The present invention also provides methods to treat a subject with insulin resistance comprising administration of D-chiro-inositol and sulfonylurea, either as concurrent single agents or as a combined composition. In particular the methods of the present invention are useful in maintaining pancreatic beta cell function/viability and thus delay diabetes progression. The methods and compositions of the present invention are particularly efficacious in treating insulin resistant subjects with a fasting blood glucose level of less than or equal to 180 mg/dL.

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SLEEVI MARK C
ALLAN GEOFFREY

PCT/US2002/013614

April 24, 2003

May 01, 2002

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INSMED INC (US)

A61K31/22; A61K31/366; A61K31/40; A61K31/7004; A61K45/06; (IPC1-7): A01N43/04; A61K31/70; C07G11/00; C07G3/00; C07H15/00; C07H17/00

US5827896A	1998-10-27
US5124360A	1992-06-23
US6020382A	2000-02-01
US6190680B1	2001-02-20

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