COMPOSITIONS AND METHODS FOR INHIBITING BONE RESORPTION

Title:

COMPOSITIONS AND METHODS FOR INHIBITING BONE RESORPTION

Document Type and Number:

WIPO Patent Application WO2002098354

Kind Code:

A3

Abstract:

The present invention relates to parenteral compositions and methods for inhibiting bone resorption in a mammal while counteracting potential local irritation at injection sites. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a farnesyl diphosphate synthase inhibiting bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a squalene synthase inhibitor.

More Like This:

JP2002544162	Title of Invention Arylamidine, Compositions Containing Such Compounds, and Methods of Use
JP4510919	Lipoxin A4 analog
JP2012508232	Hypoestoxide derivative for the treatment of malaria

Inventors:

RESZKA ALFRED A (US)
FISHER JOHN E (US)

Application Number:

PCT/US2002/017142

Publication Date:

February 27, 2003

Filing Date:

May 31, 2002

Export Citation:

Click for automatic bibliography generation Help

Assignee:

MERCK & CO INC (US)
RESZKA ALFRED A (US)
FISHER JOHN E (US)

International Classes:

A61K31/357; A61K31/663; A61K31/675; A61K45/06; A61K45/00; A61P19/08; A61P19/10; (IPC1-7): A61K31/675; A61K31/66; A61K31/335; A61K31/19

Domestic Patent References:

WO2000052198A1

2000-09-08

Foreign References:

US5254544A	1993-10-19
US5428028A	1995-06-27
US5618964A	1997-04-08

Other References: