Title:
COMPOSITIONS AND METHODS FOR INHIBITING BONE RESORPTION
Document Type and Number:
WIPO Patent Application WO2002098353
Kind Code:
A3
Abstract:
The present invention relates to parenteral compositions and methods for inhibiting bone resorption, stimulating bone formation and/or treating or preventing elevated blood cholesterol levels in a mammal while counteracting potential local irritation at injection sites. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a HMG-CoA reductase inhibitor or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a squalene synthase inhibitor.
Inventors:
RESZKA ALFRED A (US)
FISHER JOHN E (US)
FISHER JOHN E (US)
Application Number:
PCT/US2002/017141
Publication Date:
February 27, 2003
Filing Date:
May 31, 2002
Export Citation:
Assignee:
MERCK & CO INC (US)
RESZKA ALFRED A (US)
FISHER JOHN E (US)
RESZKA ALFRED A (US)
FISHER JOHN E (US)
International Classes:
A61K31/00; A61K31/194; A61K31/357; A61K31/40; A61K31/66; A61P3/06; (IPC1-7): A61K31/32; A61K31/225; A61K31/35; A61K31/44; A61K31/675
Foreign References:
| USH001286H | 1994-02-01 |
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