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Title:
COMPOSITIONS AND METHODS FOR POLYPEPTIDE ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2023/122769
Kind Code:
A3
Abstract:
Aspects of the application relate to methods and systems for obtaining information regarding multiple amino acids in a polypeptide based on binding interactions between the polypeptide and one or more amino acid recognizers. Kinetic signature information may be obtained from a series of signal pulses indicative of a series of binding events between one or more amino acid recognizers and an amino acid of a polypeptide (e.g., a terminal amino acid, an internal amino acid). The kinetic signature information (e.g., pulse duration, interpulse duration, recognition segment (RS) duration, intersegment duration) may be used to determine one or more chemical characteristics (e.g., identity, modification) of multiple amino acids of the polypeptide.

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Inventors:
REED BRIAN (US)
PANDEY MANJULA (US)
KAMBER DAVID (US)
SKINNER KENNETH (US)
Application Number:
PCT/US2022/082302
Publication Date:
August 17, 2023
Filing Date:
December 22, 2022
Export Citation:
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Assignee:
QUANTUM SI INC (US)
International Classes:
G01N33/53; G16B20/00; C07K14/47
Foreign References:
US20200209254A12020-07-02
US20200209255A12020-07-02
Attorney, Agent or Firm:
PRITZKER, Randy, J. et al. (US)
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