COMPOUND HAVING ANTIMALARIAL ACTIVITY, AND ANTIMALARIAL DRUG

Title:

COMPOUND HAVING ANTIMALARIAL ACTIVITY, AND ANTIMALARIAL DRUG

Document Type and Number:

WIPO Patent Application WO/2015/133280

Kind Code:

A1

Abstract:

　The present invention addresses the problem of providing a novel compound effective against malaria, and an application for the same. Provided is an asymmetrical compound group synthesized on the basis of a molecular design aimed at interfering with the heme toxicity avoidance mechanism of malaria.

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Inventors:

HIGUCHI TSUNEHIKO (JP)
KATO NOBUKI (JP)
UMEZAWA NAOKI (JP)

Application Number:

PCT/JP2015/054491

Publication Date:

September 11, 2015

Filing Date:

February 18, 2015

Export Citation:

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Assignee:

PUBLIC UNIV CORP NAGOYA CITY UNIV (JP)

International Classes:

C07D215/46; A61K31/4709; A61K31/4725; A61K31/506; A61P33/06; C07D401/12

Domestic Patent References:

WO2012149186A2	2012-11-01
WO2012032952A1	2012-03-15
WO2007097450A1	2007-08-30
WO2012048894A1	2012-04-19

Foreign References:

JPH10501540A	1998-02-10
JPH11500749A	1999-01-19
US20080262031A1	2008-10-23

Other References:

GIRAULT,S. ET AL.: "Antiplasmodial activity and cytotoxicity of bis-, tris- and tetraquinolines with linear or cyclic amino linkers", J.MED.CHEM., vol. 44, no. 11, 2001, pages 1658 - 1665, XP002730047, ISSN: 0022-2623
VENNERSTROM,J.L. ET AL.: "Bisquinolines.2. Antimalarial N,N-bis(7-chloroquinolin-4-yl) heteroalkanediamines", J.MED.CHEM., vol. 41, no. 22, 1998, pages 4360 - 4364, XP055135948, ISSN: 0022-2623
DATABASE REGISTRY 1 December 2011 (2011-12-01), retrieved from STN Database accession no. 1347070-66-9
DATABASE REGISTRY 6 December 2011 (2011-12-06), retrieved from STN Database accession no. 1349408-21-4
DATABASE REGISTRY 6 December 2011 (2011-12-06), retrieved from STN Database accession no. 1349611-33-1