Title:
COMPOUND HAVING SOMATOSTATIN RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/147300
Kind Code:
A1
Abstract:
Provided is a somatostatin receptor subtype 2 agonist. A compound disclosed in the present invention that is represented by general formula (I) (wherein each symbol has the same meaning as defined in the description) or a salt thereof is a low molecular compound having a strong agonistic activity to somatostatin receptor subtype 2. The compound according to the present invention can be orally administered and, therefore, can be easily taken and contribute to the reduction of patient's pain associated with a therapeutic treatment. Moreover, the compound according to the present invention has sufficiently weak hERG inhibitory activity and/or phospholipidosis effect, compared with the SSTR2 agonistic activity thereof, and, therefore, can inhibit or suppress side effects caused by the aforesaid activity and/or effect.
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Inventors:
ISHIDA AKIHARU (JP)
YOSHIDA ATSUSHI (JP)
MIYATA HIDENORI (JP)
SHONO TOMOYUKI (JP)
YOSHIDA ATSUSHI (JP)
MIYATA HIDENORI (JP)
SHONO TOMOYUKI (JP)
Application Number:
PCT/JP2018/004111
Publication Date:
August 16, 2018
Filing Date:
February 07, 2018
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
A61K31/4545; C07D401/14; A61K31/48; A61K31/5377; A61K38/00; A61K45/00; A61P1/00; A61P5/00; A61P43/00; C07D405/14
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Other References:
"Bunshi Sekkei", vol. 7, 1990, HIROKAWA SHOTEN CO, article "Iyakuhin no Kaihatsu", pages: 163 - 198
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC.
LIFE SCIENCES, vol. 40, 1987, pages 419 - 437
"The European Journal of Medicine", vol. 2, 1993, pages: 97 - 105
"Iyakuhin Tenkabutsu Jiten", 2000, YAKUJI NIPPO LTD.
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1289197-78-9
See also references of EP 3581569A4
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC.
LIFE SCIENCES, vol. 40, 1987, pages 419 - 437
"The European Journal of Medicine", vol. 2, 1993, pages: 97 - 105
"Iyakuhin Tenkabutsu Jiten", 2000, YAKUJI NIPPO LTD.
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 1289197-78-9
See also references of EP 3581569A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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