Title:
COMPOUND TRADITIONAL CHINESE MEDICINE EXTRACT FOR PREVENTION AND TREATMENT OF GLYCOMETABOLISM DISORDERS AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/094834
Kind Code:
A1
Abstract:
The compound traditional Chinese medicine extract for the prevention and treatment of glycometabolism disorders, wherein the active ingredients of the extract are composed of 1-cerotol, β-sitosterol, n-hexacosanoic acid, atractylenolide III, oleanolic acid, berberine, jateorrhizine, coptisine, tanshinol, salvianolic acid B, cyclotetracosane, 9,12-octadecadienoic acid, 5,7-dimethoxycoumarin, specnuezhenide, ginsenoside Rb1 and Rg1, notoginsenoside R1 and eucommiol. The preparative method comprises extracting crude drug Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Rhizoma Coptidis, Herba Cirsii Japonici, Cortex Eucommiae, Rhizoma Atractylodis Macrocephalae, Radix Notoginseng and Fructus Citri Sarcodactylis with C1-3 alcohol and/or water, combining total extracts, extracting the total extracts with different organic solvents (such as petroleum ether, ethyl acetate and n-butyl alcohol) to obtain effective part separately, and blending every effective part to obtain the product.
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Inventors:
GUO JIAO (CN)
BEI WEIJIAN (CN)
BEI WEIJIAN (CN)
Application Number:
PCT/CN2011/070321
Publication Date:
July 19, 2012
Filing Date:
January 17, 2011
Export Citation:
Assignee:
UNIV GUANGDONG PHARM (CN)
GUO JIAO (CN)
BEI WEIJIAN (CN)
GUO JIAO (CN)
BEI WEIJIAN (CN)
International Classes:
A61K31/7048; A61K31/015; A61K31/045; A61K31/047; A61K31/192; A61K31/20; A61K31/201; A61K31/343; A61K31/365; A61K31/37; A61K31/4375; A61K31/56; A61K31/575; A61K36/258; A61K36/28; A61K36/284; A61K36/46; A61K36/53; A61K36/718; A61K36/752; A61P3/10
Foreign References:
| CN1628786A | 2005-06-22 | |||
| CN102133221A | 2011-07-27 |
Other References:
XIE RONGRONG ET AL.: "Study on chemical constituents of compound Zhenzhu Tiaozhi.", JOURNAL OL GUANGDONG PHARMACEUTICAL COLLEGE., vol. 26, no. 4, August 2010 (2010-08-01), pages 331 - 333
LUO DUOSHENG ET AL.: "Purification procedure of the active components of compound Zhenzhu tiaozhi capsule.", JOURNAL OF GUANGDONG PHARMACEUTICAL COLLEGE., vol. 25, no. 5, October 2009 (2009-10-01), pages 449 - 451
YAO HONGXIA ET AL.: "Effects of extractions of Tiaozhikang capsules extracted with different solvents on the lipid levels in diet-induced hyperlipidemic rats.", JOURNAL OF GUANGDONG PHARMACEUTICAL COLLEGE., vol. 25, no. 6, December 2009 (2009-12-01), pages 604 - 607
LUO DUOSHENG ET AL.: "Purification procedure of the active components of compound Zhenzhu tiaozhi capsule.", JOURNAL OF GUANGDONG PHARMACEUTICAL COLLEGE., vol. 25, no. 5, October 2009 (2009-10-01), pages 449 - 451
YAO HONGXIA ET AL.: "Effects of extractions of Tiaozhikang capsules extracted with different solvents on the lipid levels in diet-induced hyperlipidemic rats.", JOURNAL OF GUANGDONG PHARMACEUTICAL COLLEGE., vol. 25, no. 6, December 2009 (2009-12-01), pages 604 - 607
Attorney, Agent or Firm:
YOGO PATENT & TRADE MARK AGENCY LIMITED COMPANY (CN)
广州粤高专利商标代理有限公司 (CN)
广州粤高专利商标代理有限公司 (CN)
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Claims: