Title:
COMPOUNDS FOR THE DEGRADATION OF EGFR KINASE
Document Type and Number:
WIPO Patent Application WO/2024/099395
Kind Code:
A1
Abstract:
Disclosed herein are novel bifunctional compounds of formula (I) formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
Inventors:
LEI BAILIN (CN)
LIU HUAQING (CN)
ZHAO YIZHOU (CN)
HAN SONGZHE (CN)
LIU WEI (CN)
QI XINZHU (CN)
WANG ZHIWEI (CN)
LIU HUAQING (CN)
ZHAO YIZHOU (CN)
HAN SONGZHE (CN)
LIU WEI (CN)
QI XINZHU (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2023/130774
Publication Date:
May 16, 2024
Filing Date:
November 09, 2023
Export Citation:
Assignee:
BEIGENE LTD (KY)
LEI BAILIN (CN)
LEI BAILIN (CN)
International Classes:
C07D498/22; A61K31/439; A61P35/00
Domestic Patent References:
| WO2022068849A1 | 2022-04-07 | |||
| WO2022012623A1 | 2022-01-20 | |||
| WO2020260252A1 | 2020-12-30 | |||
| WO2022117051A1 | 2022-06-09 | |||
| WO2022002100A1 | 2022-01-06 | |||
| WO2014121942A1 | 2014-08-14 | |||
| WO2019162323A1 | 2019-08-29 |
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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