Title:
RUXOLITINIB CRYSTAL AND PHARMACEUTICAL COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/099396
Kind Code:
A1
Abstract:
A ruxolitinib crystal and a pharmaceutical composition thereof. Specifically, provided are a ruxolitinib dihydrate crystal and a preparation method therefor. Further provided are a ruxolitinib free base in amorphous form and a preparation method therefor, and a pharmaceutical composition comprising the ruxolitinib dihydrate crystal or the ruxolitinib free base in amorphous form. The method for preparing the crystal, the amorphous substance and the pharmaceutical composition thereof is simple, and has a high product yield. In addition, the crystal has an excellent stability, hygroscopicity and processability, thereby being suitable for industrial production.
Inventors:
SHEN LIANGANG (CN)
WU XIANFENG (CN)
ZHU RONGHUA (CN)
ZHENG ZHIGUO (CN)
WU XIANFENG (CN)
ZHU RONGHUA (CN)
ZHENG ZHIGUO (CN)
Application Number:
PCT/CN2023/130777
Publication Date:
May 16, 2024
Filing Date:
November 09, 2023
Export Citation:
Assignee:
ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/395; A61P37/00
Domestic Patent References:
| WO2016074650A1 | 2016-05-19 | |||
| WO2017114461A1 | 2017-07-06 |
Foreign References:
| CN102348693A | 2012-02-08 | |||
| CN114456181A | 2022-05-10 | |||
| CN101448826A | 2009-06-03 | |||
| CN101932582A | 2010-12-29 | |||
| CN113292569A | 2021-08-24 | |||
| CN105461630A | 2016-04-06 |
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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