Title:
COMPOUNDS FOR INHIBITING INSULIN SECRETION AND METHODS RELATED THERETO
Document Type and Number:
WIPO Patent Application WO2003066035
Kind Code:
A3
Abstract:
Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following struture (I): (I)including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W1, W2, X, R1, R2, R3, R4, m and n are defined herein.
Inventors:
PEI YAZHONG (US)
JAMES IAN W (AU)
GHOSH SOUMITRA S (US)
JAMES IAN W (AU)
GHOSH SOUMITRA S (US)
Application Number:
PCT/US2003/004125
Publication Date:
January 29, 2004
Filing Date:
February 10, 2003
Export Citation:
Assignee:
MITOKOR (US)
PEI YAZHONG (US)
JAMES IAN W (AU)
GHOSH SOUMITRA S (US)
PEI YAZHONG (US)
JAMES IAN W (AU)
GHOSH SOUMITRA S (US)
International Classes:
A61K31/135; A61K31/136; A61K31/16; A61K31/165; A61K31/166; A61K31/17; A61K31/18; A61K31/192; A61K31/216; A61K31/22; A61K31/223; A61K31/36; A61K31/381; A61K31/40; A61K31/415; C07D295/18; A61K31/417; A61K31/4184; A61K31/4245; A61K31/426; A61K31/428; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/445; A61K31/495; A61K31/5375; A61K45/00; A61P3/10; A61P7/12; A61P43/00; C07C45/46; C07C45/67; C07C205/56; C07C211/29; C07C229/14; C07C229/34; C07C233/11; C07C237/04; C07C237/10; C07C237/14; C07C317/44; C07C323/29; C07C323/40; C07C323/41; C07C323/42; C07C323/44; C07C323/49; C07C323/52; C07C323/60; C07C335/18; C07D207/335; C07D211/20; C07D211/24; C07D211/96; C07D213/38; C07D213/70; C07D213/73; C07D213/80; C07D213/81; C07D213/82; C07D231/14; C07D233/20; C07D233/54; C07D233/61; C07D235/06; C07D271/06; C07D277/28; C07D277/64; C07D295/185; C07D317/68; C07D333/20; C07D413/12; C07D207/32; (IPC1-7): C07C237/10; C07C323/29; C07C323/40; C07C323/41; C07C323/42; C07C323/44; C07C323/49; C07C323/52; C07C323/60; C07C335/18; C07D207/32; C07D213/38; C07D213/70; C07D213/73; C07D213/81
Domestic Patent References:
| WO2002024204A2 | 2002-03-28 |
Other References:
KLOSA J: "SYNTHESE VON BENZOTHIAZEPINONEN, EINER NEUEN KOERPERKLASSE SYNTHESIS OF BENZOTHIAZEPINONES, A NEW CLASS OF COMPOUNDS", JOURNAL FUER PRAKTISCHE CHEMIE, LEIPZIG, DE, vol. 3, no. 1/2, 1967, pages 5 - 18, XP009019217, ISSN: 0021-8383
PEI Y ET AL.: "Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium-Calcium Exchanger : Potential Therapeutics for Type II Diabetes", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 1, 20 November 2002 (2002-11-20), pages 92 - 103, XP002260407
PEI Y ET AL.: "Efficient Syntheses of Benzothiazepines as Antagonists for the Mitochondrial Sodium-Calcium Exchanger : Potential Therapeutics for Type II Diabetes", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 1, 20 November 2002 (2002-11-20), pages 92 - 103, XP002260407
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