Title:
USE OF COMPOUNDS AND COMPOSITIONS DERIVED FORM OLIVES FOR PROTECTING CELLS AGAINST DNA DAMAGE
Document Type and Number:
WIPO Patent Application WO2003066034
Kind Code:
A3
Abstract:
Use of extracts from olive fruits, olive tree leaves, olive oil as well as olive -press waste for protecting cells from DNA damage. The evaluation of the DNA protective antioxidant activity of the extracts and the purified compounds on intact cells.
More Like This:
Inventors:
FOTINOS SPIROS (GR)
PANAITESCU LIGIA (GR)
SKLATSOUNIS ALEXIOS-LEANDRO (GR)
MITAKOU SOFIA (GR)
MAGIATIS PROKOPIOS (GR)
ALIGIANNIS NEKTARIOS (GR)
GALARIS DIMITRIOS (GR)
PANAITESCU LIGIA (GR)
SKLATSOUNIS ALEXIOS-LEANDRO (GR)
MITAKOU SOFIA (GR)
MAGIATIS PROKOPIOS (GR)
ALIGIANNIS NEKTARIOS (GR)
GALARIS DIMITRIOS (GR)
Application Number:
PCT/IB2003/001833
Publication Date:
November 13, 2003
Filing Date:
February 10, 2003
Export Citation:
Assignee:
LAVIPHARM SA (GR)
FOTINOS SPIROS (GR)
PANAITESCU LIGIA (GR)
SKLATSOUNIS ALEXIOS-LEANDRO (GR)
MITAKOU SOFIA (GR)
MAGIATIS PROKOPIOS (GR)
ALIGIANNIS NEKTARIOS (GR)
GALARIS DIMITRIOS (GR)
FOTINOS SPIROS (GR)
PANAITESCU LIGIA (GR)
SKLATSOUNIS ALEXIOS-LEANDRO (GR)
MITAKOU SOFIA (GR)
MAGIATIS PROKOPIOS (GR)
ALIGIANNIS NEKTARIOS (GR)
GALARIS DIMITRIOS (GR)
International Classes:
A61K31/366; A61P35/00; A61P39/06; G01N33/50; (IPC1-7): A61K31/366; A61P35/00; A61P39/06; G01N33/50
Other References:
GIL MATILDE ET AL: "Two glutaric acid derivatives from olives.", PHYTOCHEMISTRY (OXFORD), vol. 49, no. 5, November 1998 (1998-11-01), pages 1311 - 1315, XP004290246, ISSN: 0031-9422
FORD J H; ET AL: "Organic preparations of calcium elenolate from olive press juice", ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, vol. 4, no. 7, 1972, pages 97 - 104, XP009014158
JOHNSON MELISSA K ET AL: "Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.", MUTATION RESEARCH, vol. 459, no. 3, 28 April 2000 (2000-04-28), pages 211 - 218, XP002248985, ISSN: 0027-5107
DEIANA MONICA ET AL: "Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol.", FREE RADICAL BIOLOGY & MEDICINE, vol. 26, no. 5-6, March 1999 (1999-03-01), pages 762 - 769, XP002249023, ISSN: 0891-5849
VISIOLI F ET AL: "'WASTE WATERS FROM OLIVE OIL PRODUCTION ARE RICH IN NATURAL ANTIOXIDANTS", EXPERIENTIA, BIRKHAUSER VERLAG. BASEL, CH, vol. 51, no. 1, 1995, pages 32 - 34, XP000961166, ISSN: 0014-4754
FORD J H; ET AL: "Organic preparations of calcium elenolate from olive press juice", ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, vol. 4, no. 7, 1972, pages 97 - 104, XP009014158
JOHNSON MELISSA K ET AL: "Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.", MUTATION RESEARCH, vol. 459, no. 3, 28 April 2000 (2000-04-28), pages 211 - 218, XP002248985, ISSN: 0027-5107
DEIANA MONICA ET AL: "Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol.", FREE RADICAL BIOLOGY & MEDICINE, vol. 26, no. 5-6, March 1999 (1999-03-01), pages 762 - 769, XP002249023, ISSN: 0891-5849
VISIOLI F ET AL: "'WASTE WATERS FROM OLIVE OIL PRODUCTION ARE RICH IN NATURAL ANTIOXIDANTS", EXPERIENTIA, BIRKHAUSER VERLAG. BASEL, CH, vol. 51, no. 1, 1995, pages 32 - 34, XP000961166, ISSN: 0014-4754
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