Title:
β−KETOAMIDE COMPOUNDS AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/016266
Kind Code:
A1
Abstract:
β−Ketoamide compounds represented by the following general formula [I]: [I] wherein each symbol is as defined in the description&semi pharmaceutically acceptable salts thereof and anti−HIV agents containing these compounds. Because of having an HIV integrase inhibitory activity, the above compounds are useful as anti−HIV agents to be used in remedies or preventives for AIDS. Further efficacious anti−HIV agents can be obtained by combining the compounds with other anti−HIV agents such as a protease inhibitor or a reverse transcriptase inhibitor. Because of showing a specifically high inhibitory activity on integrase, these compounds are usable as safe drugs with little side effects on the human body.
Inventors:
KATOH SUSUMU (JP)
MIYAZAKI SUSUMU (JP)
HABUKA NORIYUKI (JP)
MIYAZAKI SUSUMU (JP)
HABUKA NORIYUKI (JP)
Application Number:
PCT/JP2002/008211
Publication Date:
February 27, 2003
Filing Date:
August 12, 2002
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
KATOH SUSUMU (JP)
MIYAZAKI SUSUMU (JP)
HABUKA NORIYUKI (JP)
KATOH SUSUMU (JP)
MIYAZAKI SUSUMU (JP)
HABUKA NORIYUKI (JP)
International Classes:
C07C235/80; C07D213/68; C07D231/12; C07D233/64; C07D249/08; C07D277/24; C07D277/46; (IPC1-7): C07C235/80; C07C237/42; C07C311/46; C07C317/40; C07D213/30; C07D213/68; C07D213/75; C07D215/12; C07D215/38; C07D231/12; C07D233/64; C07D239/26; C07D241/12; C07D249/08; C07D257/04; C07D261/08; C07D263/14; C07D271/10; C07D277/24; C07D277/46; C07D295/18; C07D295/22; C07D307/81; C07D317/66; C07D401/12; C07D403/12; C07D417/12
Domestic Patent References:
| WO2001096283A2 | 2001-12-20 | |||
| WO1999062520A1 | 1999-12-09 |
Foreign References:
| JPH07267903A | 1995-10-17 |
Attorney, Agent or Firm:
Takashima, Hajime (2-14 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka, JP)
Download PDF: