Title:
COMPOUNDS AND THEIR USES AS MIF INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2023/020534
Kind Code:
A1
Abstract:
Provided herein are compounds of Formula I, II, and III, which can be used as macrophage migration inhibitory factor (MIF) inhibitors; methods for the production of the compounds; pharmaceutical compositions comprising the compounds; as well as uses and methods for treating a disease mediated by MIF by administering the compounds.
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Inventors:
XI JIANBEI (CN)
FAN GUOHUANG (CN)
WANG JIANFEI (CN)
FAN GUOHUANG (CN)
WANG JIANFEI (CN)
Application Number:
PCT/CN2022/113023
Publication Date:
February 23, 2023
Filing Date:
August 17, 2022
Export Citation:
Assignee:
NANJING IMMUNOPHAGE BIOTECH CO LTD (CN)
International Classes:
C07D409/06; A61K31/055; A61K31/428; A61K31/4709; A61P9/00; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/00; C07D213/00; C07D215/26; C07D277/62
Domestic Patent References:
| WO2011066864A1 | 2011-06-09 | |||
| WO2013192423A2 | 2013-12-27 | |||
| WO2011106226A2 | 2011-09-01 |
Foreign References:
| CN105566293A | 2016-05-11 |
Other References:
ZAPATERO MARIA CLEOFÉ, PALOMA PÉREZ, MARÍA JESÚS VÁZQUEZ, GONZALO COLMENAREJO, MAITE DE LOS FRAILES, FERNANDO RAMÓN : "Discovery of novel inhibitors of the tautomerase activity of macrophage migration inhibitory factor (MIF)", JOURNAL OF BIOMOLECULAR SCREENING SOCIETY FOR LABORATORY AUTOMATION AND SCREENING, vol. 21, no. 5, 31 December 2016 (2016-12-31), pages 446 - 458, XP055882734, DOI: 10.1177/1087057116633997
SHERGALIS ANDREA, XUE DING, GHARBIA FATMA Z., DRIKS HANNAH, SHRESTHA BINITA, TANWEER AMINA, CROMER KIRIN, LJUNGMAN MATS, NEAMATI N: "Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 18, 24 September 2020 (2020-09-24), US , pages 10263 - 10286, XP093037489, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00728
DUAN ZHE; LIU JINGQIU; NIU LIPING; WANG JUN; FENG MINGQIAN; CHEN HUA; LUO CHENG: "Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, no. 15, 28 May 2019 (2019-05-28), AMSTERDAM, NL, pages 3229 - 3236, XP085742161, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.05.040
MCLEAN, L.R. ; ZHANG, Y. ; LI, H. ; LI, Z. ; LUKASCZYK, U. ; CHOI, Y.M. ; HAN, Z. ; PRISCO, J. ; FORDHAM, J. ; TSAY, J.T. ; REILIN: "Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 23, 1 December 2009 (2009-12-01), Amsterdam NL , pages 6717 - 6720, XP026736091, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.09.106
SHERGALIS ANDREA, XUE DING, GHARBIA FATMA Z., DRIKS HANNAH, SHRESTHA BINITA, TANWEER AMINA, CROMER KIRIN, LJUNGMAN MATS, NEAMATI N: "Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 18, 24 September 2020 (2020-09-24), US , pages 10263 - 10286, XP093037489, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00728
DUAN ZHE; LIU JINGQIU; NIU LIPING; WANG JUN; FENG MINGQIAN; CHEN HUA; LUO CHENG: "Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, no. 15, 28 May 2019 (2019-05-28), AMSTERDAM, NL, pages 3229 - 3236, XP085742161, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.05.040
MCLEAN, L.R. ; ZHANG, Y. ; LI, H. ; LI, Z. ; LUKASCZYK, U. ; CHOI, Y.M. ; HAN, Z. ; PRISCO, J. ; FORDHAM, J. ; TSAY, J.T. ; REILIN: "Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 23, 1 December 2009 (2009-12-01), Amsterdam NL , pages 6717 - 6720, XP026736091, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.09.106
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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