Title:
CONDENSED HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/210586
Kind Code:
A1
Abstract:
[Problem] To address the problem of providing a novel condensed heterocyclic compound which has a sepiapterin reductase-inhibiting activity and is particularly useful for the treatment of a pain. [Solution] Provided are a novel condensed heterocyclic compound represented by formula (I) (wherein each substituent is as defined in detail in the description; R1 represents a hydrocarbon group or the like; R2 and R3 independently represent a hydrogen atom or the like; R4 represents a substituent as defined in the description; X represents a substituent as defined in the description; and Y represents a substituent as defined in the description), a tautomer or a pharmaceutically acceptable salt of the compound, or a solvate of the compound, the tautomer or the pharmaceutically acceptable salt.
Inventors:
KAMAURA MASAHIRO (JP)
INABA YUSUKE (JP)
SHINTANI YUSUKE (JP)
KUWANO YUKI (JP)
NAKAO MOEMI (JP)
NAGAI HIROSHI (JP)
KUROSE NORIYUKI (JP)
TAKAYA KENJI (JP)
NAKAJIMA MADO (JP)
INABA YUSUKE (JP)
SHINTANI YUSUKE (JP)
KUWANO YUKI (JP)
NAKAO MOEMI (JP)
NAGAI HIROSHI (JP)
KUROSE NORIYUKI (JP)
TAKAYA KENJI (JP)
NAKAJIMA MADO (JP)
Application Number:
PCT/JP2021/015351
Publication Date:
October 21, 2021
Filing Date:
April 13, 2021
Export Citation:
Assignee:
NISSAN CHEMICAL CORP (JP)
SHIONOGI & CO (JP)
SHIONOGI & CO (JP)
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61P25/04; A61P43/00
Domestic Patent References:
| WO2009039323A1 | 2009-03-26 | |||
| WO2011047156A1 | 2011-04-21 | |||
| WO2017059191A1 | 2017-04-06 |
Foreign References:
| JP2018529739A | 2018-10-11 | |||
| JP2007511520A | 2007-05-10 |
Other References:
SMITH G K, ET AL.: "New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 267, no. 8, 15 March 1992 (1992-03-15), US , pages 5599 - 5607, XP002692284, ISSN: 0021-9258
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 24, no. 17, 30 July 2020 (2020-07-30), pages 9495 - 9506, XP055868042, DOI: 10.1111/jcmm.15608
LANCET NEUROL., vol. 10, 2011, pages 721 - 733
NATURE MEDICINE, vol. 12, no. 11, 2006, pages 1269 - 1277
"Design of Prodrugs", 1985, ELSEVIER
JIE JACK LI: "Revised Organic Name Reactions, Mechanism and Essence", vol. I-VII, L. F. TIETZE, TH. EICHER, NANKODO CO., LTD., article "Modern Organic Synthesis in the Laboratory"
"Strategic Applications of Named Reactions in Organic Synthesis", vol. 1-14, 1989, KAGAKU-DOUJIN PUBLISHING CO, INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE INC
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME PUBLISHERS
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 24, no. 17, 30 July 2020 (2020-07-30), pages 9495 - 9506, XP055868042, DOI: 10.1111/jcmm.15608
LANCET NEUROL., vol. 10, 2011, pages 721 - 733
NATURE MEDICINE, vol. 12, no. 11, 2006, pages 1269 - 1277
"Design of Prodrugs", 1985, ELSEVIER
JIE JACK LI: "Revised Organic Name Reactions, Mechanism and Essence", vol. I-VII, L. F. TIETZE, TH. EICHER, NANKODO CO., LTD., article "Modern Organic Synthesis in the Laboratory"
"Strategic Applications of Named Reactions in Organic Synthesis", vol. 1-14, 1989, KAGAKU-DOUJIN PUBLISHING CO, INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE INC
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME PUBLISHERS
Attorney, Agent or Firm:
HANABUSA PATENT & TRADEMARK OFFICE (JP)
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