CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS

Title:

CONDENSED INDOLINE DERIVATIVES AND THEIR USE AS 5HT, IN PARTICULAR 5HT2C, RECEPTOR LIGANDS

Document Type and Number:

WIPO Patent Application WO2001012602

Kind Code:

A8

Abstract:

A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.

Inventors:

ROFFEY JONATHAN RICHARD ANTHON (GB)
DAVIDSON JAMES EDWARD PAUL (GB)
MANSELL HOWARD LANGHAM (GB)
HAMLYN RICHARD JOHN (GB)
ADAMS DAVID REGINALD (GB)

Application Number:

PCT/GB2000/003008

Publication Date:

April 05, 2001

Filing Date:

August 04, 2000

Export Citation:

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Assignee:

VERNALIS RES LTD (GB)
ROFFEY JONATHAN RICHARD ANTHON (GB)
DAVIDSON JAMES EDWARD PAUL (GB)
MANSELL HOWARD LANGHAM (GB)
HAMLYN RICHARD JOHN (GB)
ADAMS DAVID REGINALD (GB)

International Classes:

A61K31/4045; A61K31/407; A61K31/4745; A61P1/04; A61P3/04; A61P7/02; A61P9/10; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D209/60; C07D209/70; C07D471/04; C07D491/04; C07D491/048; C07D491/056; C07D495/04; (IPC1-7): C07D209/60; A61K31/395; A61P3/04; C07D491/04; C07D495/04; C07D209/70

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