Title:
NOVEL ANILIDE DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2001/012601
Kind Code:
A1
Abstract:
Anilide derivatives of general formula (1) or salts thereof; and drugs containing the same as the active ingredient: [wherein R?1¿ is alkoxy or the like; R?2¿ is alkoxy or the like; R?3¿ is hydrogen or the like; R?4¿ is alkyl or the like; A is nitrogen or CR?6¿ (wherein R?6¿ is hydrogen or the like); B is nitrogen, CH, or the like; W is aryl or the like; D is oxygen or the like; E is an aromatic hydrocarbon ring or the like; G is a group of formula (a) or the like; X is oxygen or the like; Y is alkylene or the like; and the linkage between G and the adjacent nitrogen atom is a double or single bond (with the proviso that only when the linkage is a single bond, R?5¿ is hydrogen or the like)]. The compounds exhibit excellent MTP-inhibitory activities and so on, and are useful as preventive and therapeutic drugs for hyperlipidemia, arteriosclerosis and so on.
Inventors:
YOKOMOTO MASAHARU (JP)
INOUE SATOSHI (JP)
HIRAO YUZO (JP)
TAMURA KOICHI (JP)
AMANO HIROTAKA (JP)
INOKUMA KENICHI (JP)
OSAKI MITSUHIKO (JP)
AKAMATSU HISASHI (JP)
AOKI SHIZUKA (JP)
INOUE SATOSHI (JP)
HIRAO YUZO (JP)
TAMURA KOICHI (JP)
AMANO HIROTAKA (JP)
INOKUMA KENICHI (JP)
OSAKI MITSUHIKO (JP)
AKAMATSU HISASHI (JP)
AOKI SHIZUKA (JP)
Application Number:
PCT/JP2000/005402
Publication Date:
February 22, 2001
Filing Date:
August 11, 2000
Export Citation:
Assignee:
WAKUNAGA PHARMA CO LTD (JP)
YOKOMOTO MASAHARU (JP)
INOUE SATOSHI (JP)
HIRAO YUZO (JP)
TAMURA KOICHI (JP)
AMANO HIROTAKA (JP)
INOKUMA KENICHI (JP)
OSAKI MITSUHIKO (JP)
AKAMATSU HISASHI (JP)
AOKI SHIZUKA (JP)
YOKOMOTO MASAHARU (JP)
INOUE SATOSHI (JP)
HIRAO YUZO (JP)
TAMURA KOICHI (JP)
AMANO HIROTAKA (JP)
INOKUMA KENICHI (JP)
OSAKI MITSUHIKO (JP)
AKAMATSU HISASHI (JP)
AOKI SHIZUKA (JP)
International Classes:
C07D211/18; A61K31/403; A61K31/4035; A61K31/4427; A61K31/445; A61K31/506; A61K31/5375; A61K31/5377; A61P3/06; A61P9/10; C07D209/44; C07D265/30; C07D401/12; C07D403/12; (IPC1-7): C07D209/44; A61K31/403; A61K31/4035; A61K31/433; A61K31/445; A61K31/4709; A61K31/506; A61K31/517; A61K31/5375; A61K31/5377; A61P3/06; A61P9/10; C07D209/52; C07D211/58; C07D265/30; C07D285/12; C07D401/12; C07D401/14; C07D403/14; C07D405/14; C07D409/14
Domestic Patent References:
| WO1998027979A1 | 1998-07-02 | |||
| WO1999031085A1 | 1999-06-24 |
Foreign References:
| JPH1135555A | 1999-02-09 |
Attorney, Agent or Firm:
Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku, Tokyo, JP)
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