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Title:
CONDENSED RING COMPOUNDS THAT INHIBIT H-PGDS
Document Type and Number:
WIPO Patent Application WO/2021/256569
Kind Code:
A1
Abstract:
The present invention provides: compounds that have an inhibitory activity on hematopoietic prostaglandin D synthase (H-PGDS) and are useful for the prevention or treatment of diseases in which the synthase is implicated; and drug compositions that contain the compounds. In specific terms, the present invention provides compounds given by formula (I) or a pharmaceutically acceptable salt thereof. [In formula (I), R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 represents a hydrogen atom, etc.; R5 represents a hydrogen atom, etc.; W represents an oxygen atom, etc.; and X represents a C1-6 alkyl group, etc.]

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Inventors:
BABA MOTOAKI (JP)
OKUI TAKUMA (JP)
ITOH YOSHIKI (JP)
Application Number:
PCT/JP2021/023271
Publication Date:
December 23, 2021
Filing Date:
June 18, 2021
Export Citation:
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Assignee:
SATO PHARMA (JP)
International Classes:
A61P1/00; A61K31/4355; A61K31/437; A61K31/444; A61K31/497; A61K31/501; A61K31/506; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P21/04; A61P25/00; A61P27/00; A61P29/00; A61P37/08; A61P43/00; C07D471/04; C07D491/048
Domestic Patent References:
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Foreign References:
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Other References:
CARRON, C. P. ET AL.: "Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS", ACS MEDICINAL CHEMISTRY LETTERS, vol. 1, no. 2, 2 February 2010 (2010-02-02), pages 59 - 63, XP055508740, DOI: 10.1021/m1900025z
BIOORG. MED. CHEM. LETT., vol. 22, 2012, pages 3795 - 3799
J. MED. CHEM., vol. 53, 2010, pages 5536 - 5548
BIOORG. MED. CHEM. LETT., vol. 34, 2021, pages 127759
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
Attorney, Agent or Firm:
TANAKA Shinichiro et al. (JP)
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