Title:
CONJUGATE AND THE PREPARING METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/214054
Kind Code:
A1
Abstract:
Provided herein are a conjugate and the preparing method and use thereof. The conjugate of formula 1, M- [ (L1) a- (L2) b- (D) c] 1, wherein M is a biological macromolecule having a nucleophilic functional group, M is linked to L1 with the nucleophilic functional of M, D is a functional molecule, L2 is a linker, and L1 is a compound of formula I.
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Inventors:
LI JIE (CN)
WU QINGSONG (CN)
SHA WANXING (CN)
YANG YANG (CN)
WU QINGSONG (CN)
SHA WANXING (CN)
YANG YANG (CN)
Application Number:
PCT/CN2022/085706
Publication Date:
October 13, 2022
Filing Date:
April 08, 2022
Export Citation:
Assignee:
UNIV NANJING (CN)
International Classes:
A61K47/68; A61K47/65; A61P35/00; C07C309/81
Foreign References:
| CN104185477A | 2014-12-03 | |||
| CN106957207A | 2017-07-18 | |||
| CN102076331A | 2011-05-25 | |||
| CN105503879A | 2016-04-20 |
Other References:
CHINTHAKINDI PRAVEEN K., ARVIDSSON PER I.: "Sulfonyl Fluorides (SFs): More Than Click Reagents?", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2018, no. 27-28, 1 August 2018 (2018-08-01), DE , pages 3648 - 3666, XP055976715, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800464
MUKHERJEE H., DEBRECZENI J., BREED J., TENTARELLI S., AQUILA B., DOWLING J. E., WHITTY A., GRIMSTER N. P.: "A study of the reactivity of S (VI) –F containing warheads with nucleophilic amino-acid side chains under physiological conditions", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 15, no. 45, 1 January 2017 (2017-01-01), pages 9685 - 9695, XP055976717, ISSN: 1477-0520, DOI: 10.1039/C7OB02028G
MUKHERJEE H., DEBRECZENI J., BREED J., TENTARELLI S., AQUILA B., DOWLING J. E., WHITTY A., GRIMSTER N. P.: "A study of the reactivity of S (VI) –F containing warheads with nucleophilic amino-acid side chains under physiological conditions", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 15, no. 45, 1 January 2017 (2017-01-01), pages 9685 - 9695, XP055976717, ISSN: 1477-0520, DOI: 10.1039/C7OB02028G
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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