CONNEXIN 26 INHIBITORS AND CANCER METASTASIS INHIBITORS

WIPO Patent Application WO/2004/060398

A1

As represented by the following general formula (1), a connexin 26 inhibitor and a cancer metastasis inhibitor having a cis-oxirane structure and a terminal amide structure: (1) wherein R represents hydrogen or hydrocarbyl; X represents hydrogen, methanesulfonyl, ethanesulfonyl, acetyl, trifluoroacetyl, hydroxyl, alkoxy or amino; m is an integer of from 4 to 10; and n is an integer of from 4 to 7. This compound is a novel cancer metastasis inhibitor which specifically inhibits the function of connexin 26.

KITA YASUYUKI (JP)
NOJIMA HIROSHI (JP)
ITO AKIHIKO (JP)
MORITA NOBUYOSHI (JP)

PCT/JP2003/015243

July 22, 2004

November 28, 2003

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JAPAN SCIENCE & TECH AGENCY (JP)
KITA YASUYUKI (JP)
NOJIMA HIROSHI (JP)
ITO AKIHIKO (JP)
MORITA NOBUYOSHI (JP)

A61K31/16; A61K31/336; A61P35/04; (IPC1-7): A61K45/00; A61K31/16; A61K31/336; A61P35/04

EP1072687A2	2001-01-31
JP2001523695A	2001-11-27

R. BRUZZONE ET AL: "Connections with connexins: the molecular basis of direct intercellular signaling", EUR. J. BIOCHEM., vol. 238, 1996, pages 1 - 27, XP002913288
LEE S.W. ET AL: "Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines", J. OF CELL BIOLOGY, vol. 118, no. 5, 1992, pages 1213 - 1221, XP002946828
See also references of EP 1582219A4

Hara, Kenzo (Daiwa Minamimorimachi Building 2-6, Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, JP)

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