Title:
IMMUNOGENIC COMPOSITIONS CONTAINING PHOSPHOLPID
Document Type and Number:
WIPO Patent Application WO2004060396
Kind Code:
A3
Abstract:
Immunogenic compositions containing phospholipid adjuvants, including microparticle and emulsion compositions. According to one aspect of the invention, an immunogenic microparticle composition is provided that comprises: water; a polymer microparticle comprising a biodegradable polymer, e.g., a polymer selected from a poly(alpha-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and a polycyanoacrylate; an antigen adsorbed to the microparticle; and a phospholipid compound, e.g., a synthetic phospholipid compound comprising: (i) one or more phosphoryl groups independently selected from a phosphato group and a phosphodiester group; (ii) a plurality of linear alkane groups. According to another aspect of the invention an immunogenic emulsion composition is provided that comprises: water; a metabolizable oil; an emulsifying agent; an antigen; and a phospholipid compound, e.g., a synthetic phospholipid compound like that above. The emulsion composition is an oil-in-water emulsion having oil and aqueous phases, in which the oil phase is in the form of oil droplets, substantially all of which are less than 1 micron in diameter.
Inventors:
O'HAGAN DEREK
Application Number:
PCT/US2003/041412
Publication Date:
April 28, 2005
Filing Date:
December 29, 2003
Export Citation:
Assignee:
CHIRON CORP (US)
International Classes:
A61K9/00; A61K9/107; A61K9/16; A61K9/19; A61K39/00; A61K39/39; A61K47/06; A61K47/26; (IPC1-7): A61K39/00; A61K39/39; A61K9/00; A61K9/16; A61K9/107
Domestic Patent References:
| WO2000056282A1 | 2000-09-28 | |||
| WO2002026212A2 | 2002-04-04 |
Foreign References:
| US6290973B1 | 2001-09-18 | |||
| US20020025329A1 | 2002-02-28 |
Other References:
HAWKINS LYNN D ET AL: "A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 300, no. 2, February 2002 (2002-02-01), pages 655 - 661, XP002286603, ISSN: 0022-3565
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