Title:
CRISPR-CAS EFFECTOR PROTEIN, GENE EDITING SYSTEM THEREFOR, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2023/241669
Kind Code:
A1
Abstract:
Provided are a CRISPR-Cas effector protein, a gene editing system therefor, and an application. The CRISPR-Cas effector protein comprises a protein which is at least 70% identical to the amino acid sequence of any one of SEQ ID NOs: 1 to 5. The present application can solve the problem in the prior art of low CRISPR/Cas system cutting efficiency, and is suitable for the field of gene editing.
More Like This:
Inventors:
ZHANG HONGLING (CN)
REN WENDAN (CN)
REN WENDAN (CN)
Application Number:
PCT/CN2023/100529
Publication Date:
December 21, 2023
Filing Date:
June 15, 2023
Export Citation:
Assignee:
YAOTANG SHANGHAI BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N9/22; A61K38/46; A61K48/00; A61P3/06; A61P7/06; A61P13/12; A61P21/00; A61P25/14; A61P25/28; A61P35/00; A61P35/02; A61P43/00; C07K19/00; C12N5/10; C12N15/113; C12N15/55; C12N15/62; C12N15/70; C12N15/82; C12N15/85
Foreign References:
| CN114921439A | 2022-08-19 | |||
| CN113308451A | 2021-08-27 | |||
| CN113106081A | 2021-07-13 | |||
| CN110418647A | 2019-11-05 | |||
| US20200063126A1 | 2020-02-27 |
Other References:
DATABASE Protein 29 December 2020 (2020-12-29), ANONYMOUS : "Chain A, Cas12i2", XP093117584, retrieved from NCBI Database accession no. PDB: 6LTP_A
LIU KE, LIN GUIHONG, LIU KUN, ZHOU WEI, WANG FENGQING, DONGZHI WEI: "Mining, engineering and functional expansion of CRISPR/Cas systems", SYNTHETIC BIOLOGY JOURNAL., vol. 4, no. 1, 13 May 2022 (2022-05-13), pages 47 - 66, XP093117588, DOI: 10.12211/2096-8280.2021-022
ZHANG HENG; LI ZHUANG; XIAO RENJIAN; CHANG LEIFU: "Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease", NATURE STRUCTURAL & MOLECULAR BIOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 27, no. 11, 7 September 2020 (2020-09-07), New York , pages 1069 - 1076, XP037295140, ISSN: 1545-9993, DOI: 10.1038/s41594-020-0499-0
LIU KE, LIN GUIHONG, LIU KUN, ZHOU WEI, WANG FENGQING, DONGZHI WEI: "Mining, engineering and functional expansion of CRISPR/Cas systems", SYNTHETIC BIOLOGY JOURNAL., vol. 4, no. 1, 13 May 2022 (2022-05-13), pages 47 - 66, XP093117588, DOI: 10.12211/2096-8280.2021-022
ZHANG HENG; LI ZHUANG; XIAO RENJIAN; CHANG LEIFU: "Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease", NATURE STRUCTURAL & MOLECULAR BIOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 27, no. 11, 7 September 2020 (2020-09-07), New York , pages 1069 - 1076, XP037295140, ISSN: 1545-9993, DOI: 10.1038/s41594-020-0499-0
Attorney, Agent or Firm:
KANGXIN PARTNERS , P.C. (CN)
Download PDF:
Previous Patent: TENSION MECHANISM, TRANSMISSION DEVICE AND MECHANICAL ARM
Next Patent: END-TO-END COMMUNICATION ESTABLISHMENT METHOD AND SYSTEM
Next Patent: END-TO-END COMMUNICATION ESTABLISHMENT METHOD AND SYSTEM