Title:
CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/166981
Kind Code:
A1
Abstract:
This cross-linked nucleoside is a compound indicated by formula (I). This cross-linked nucleoside: can be used as a substitute for a phosphorothioate-modified nucleic acid, which has the risk of accumulating in a specific organ; and has excellent industrial productivity.
Inventors:
OBIKA SATOSHI (JP)
YAMAGUCHI TAKAO (JP)
SAKURAI YOTA (JP)
YAMAMOTO CHIKA (JP)
SUGITA KEI (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
YAMAGUCHI TAKAO (JP)
SAKURAI YOTA (JP)
YAMAMOTO CHIKA (JP)
SUGITA KEI (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
Application Number:
PCT/JP2021/006017
Publication Date:
August 26, 2021
Filing Date:
February 17, 2021
Export Citation:
Assignee:
UNIV OSAKA (JP)
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NAT INSTITUTE OF HEALTH SCIENCES (JP)
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NAT INSTITUTE OF HEALTH SCIENCES (JP)
International Classes:
A61K48/00; C07D493/08; C07H21/04; C12N15/113
Domestic Patent References:
WO2009100320A2 | 2009-08-13 | |||
WO2011017521A2 | 2011-02-10 | |||
WO2009067647A1 | 2009-05-28 | |||
WO2008154401A2 | 2008-12-18 |
Foreign References:
US20120002014A1 | 2012-01-05 | |||
US20120021515A1 | 2012-01-26 |
Other References:
HERDEWIJN, P.: "Nucleic acids with a six-membered 'carbohydrate' mimic in the backbone", CHEMISTRY & BIODIVERSITY, vol. 7, 2010, pages 1 - 59, XP055849799
VAN, A ET AL.: "1,5-anhydrohexitol nucleic acids, a new promising antisense construct", ANGEW CHEM. INT. ED., vol. 34, no. 12, 1995, pages 1338,1339, XP000605755, DOI: 10.1002/anie.199513381
S. OBIKA ET AL., TETRAHEDRON LETT., vol. 38, 1997, pages 8735 - 8738
S. SINGH ET AL., CHEM. COMMUN., 1998, pages 455 - 456
E. SWAYZE ET AL., NUCLEIC ACIDS RES., vol. 35, 2007, pages 687 - 700
A. AERSCHOT ET AL., ANGEW. CHEM. INT. ED., vol. 34, 1995, pages 1338 - 1339
P. HERDEWIJN, P. CHEM. BIODIVERSITY, vol. 7, 2010, pages 1 - 59
M. EGLI ET AL., J. AM. CHEM. SOC., vol. 133, 2011, pages 16642 - 16649
B. T. LE ET AL., CHEM. COMMUN., vol. 52, 2016, pages 13467 - 13470
M. KUWAHARA ET AL., NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
MALLIKHARJUNA R. LAMBU ET AL., J. MED. CHEM., vol. 56, 2013, pages 6123 - 6124
VAN, A ET AL.: "1,5-anhydrohexitol nucleic acids, a new promising antisense construct", ANGEW CHEM. INT. ED., vol. 34, no. 12, 1995, pages 1338,1339, XP000605755, DOI: 10.1002/anie.199513381
S. OBIKA ET AL., TETRAHEDRON LETT., vol. 38, 1997, pages 8735 - 8738
S. SINGH ET AL., CHEM. COMMUN., 1998, pages 455 - 456
E. SWAYZE ET AL., NUCLEIC ACIDS RES., vol. 35, 2007, pages 687 - 700
A. AERSCHOT ET AL., ANGEW. CHEM. INT. ED., vol. 34, 1995, pages 1338 - 1339
P. HERDEWIJN, P. CHEM. BIODIVERSITY, vol. 7, 2010, pages 1 - 59
M. EGLI ET AL., J. AM. CHEM. SOC., vol. 133, 2011, pages 16642 - 16649
B. T. LE ET AL., CHEM. COMMUN., vol. 52, 2016, pages 13467 - 13470
M. KUWAHARA ET AL., NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
MALLIKHARJUNA R. LAMBU ET AL., J. MED. CHEM., vol. 56, 2013, pages 6123 - 6124
Attorney, Agent or Firm:
NAKAMICHI, Yoshihiro et al. (JP)
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