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Title:
CRYSTAL FORM OF 4-ISOPROPYLPHENYL GLUCITOL COMPOUND AND PROCESS FOR PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/023598
Kind Code:
A1
Abstract:
Provided are a highly stable crystal of (1S)-1,5-anhydro-1-[5-(4-{(1E)-4-[(1-{[2-(dimethylamino)- ethyl]amino}-2-methyl-1-oxopropan-2-yl)amino]-3,3-dimethyl-4-oxobut-1-en-1-yl}benzyl)-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol and a process for producing the crystal. Specifically provided are an ethanol solvate having the physical properties mentioned below and another multiple crystal forms derived from the ethanol solvate: (a) peaks appear at 2θ = 5.9˚, 17.1˚, 17.6˚ and 21.5˚ in powder X-ray diffraction (Cu-Kα); (b) characteristic absorption bands appear at 3538 cm-1, 3357 cm-1, 2964 cm-1, 1673 cm-1, 1634 cm-1 and 1505 cm-1 in infrared absorption spectra; and (c) the melting point is about 111˚C.

Inventors:
KIMURA YOSHIHIRO (JP)
IMURA KOREAKI (JP)
OSAKI NAOTO (JP)
MATSUSHIMA AYUMI (JP)
Application Number:
PCT/JP2011/068736
Publication Date:
February 23, 2012
Filing Date:
August 19, 2011
Export Citation:
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Assignee:
TAISHO PHARMA CO LTD (JP)
KIMURA YOSHIHIRO (JP)
IMURA KOREAKI (JP)
OSAKI NAOTO (JP)
MATSUSHIMA AYUMI (JP)
International Classes:
C07D309/10
Domestic Patent References:
WO2010095768A12010-08-26
WO2004014932A12004-02-19
WO2002098893A12002-12-12
WO2004014932A12004-02-19
WO2004018491A12004-03-04
WO2004019958A12004-03-11
WO2005121161A12005-12-22
WO2004050122A12004-06-17
WO2007136116A22007-11-29
Foreign References:
JP2009537509A2009-10-29
JP2009107997A2009-05-21
Other References:
See also references of EP 2607359A4
PAN XR ET AL., DIABETES CARE, vol. 20, 1997, pages 537
M TOMINAGA ET AL., DIABETES CARE, vol. 22, 1999, pages 920
J.-L. CHIASSON ET AL., LANCENT, vol. 359, pages 2072,2002
E. M. WRIGHT, AM. J. PHYSIOL. RENAL. PHYSIOL., vol. 280, 2001, pages F10
G. TOGGENBURGER ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 688, 1982, pages 557
FOLIA PHARMACOL. JPN., vol. 113, 1999, pages 19
J. ORG. CHEM., vol. 65, 2000, pages 8402
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
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Claims: