Title:
CRYSTAL FORM II OF OBETICHOLIC ACID, PREPARATION METHOD AND USAGE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/092702
Kind Code:
A1
Abstract:
Provided are a crystal form II of obeticholic acid, preparation method and usage thereof. In an X-ray powder diffraction pattern, the crystal form II of obeticholic acid has characteristic peaks at 2θ values of 4.9° ± 0.2°, 5.3 ± 0.2°, 6.3° ± 0.2°, 7.2° ± 0.2°, 7.7° ± 0.2°, 8.9° ± 0.2°, 9.9° ± 0.2°, 10.6° ± 0.2°, 11.0° ± 0.2°, 12.4° ± 0.2°, 12.6° ± 0.2°, 14.9° ± 0.2°, 15.3° ± 0.2°, 15.9° ± 0.2°, 16.5° ± 0.2°, 16.7° ± 0.2°, 18.0° ± 0.2°, 19.0° ± 0.2°, 20.6° ± 0.2°, 21.0° ± 0.2° and 24.7° ± 0.2°.
Inventors:
QIN ZHIPING (CN)
WANG HUOJIAN (CN)
LENG ZHENGWEN (CN)
QIAN LINA (CN)
CUI JIAN (CN)
WANG HUOJIAN (CN)
LENG ZHENGWEN (CN)
QIAN LINA (CN)
CUI JIAN (CN)
Application Number:
PCT/CN2016/108283
Publication Date:
June 08, 2017
Filing Date:
December 01, 2016
Export Citation:
Assignee:
WATERSTONE PHARMACEUTICALS (WUHAN) CO LTD (CN)
International Classes:
C07J9/00; A61K31/575; A61P1/16
Domestic Patent References:
| WO2013192097A1 | 2013-12-27 |
Foreign References:
| CN105777836A | 2016-07-20 | |||
| CN105859814A | 2016-08-17 | |||
| CN105801653A | 2016-07-27 |
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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