Title:
CRYSTAL FORM OF SPIROCYCLIC AMINE ARYL PHOSPHORUS OXIDE COMPOUND AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/027565
Kind Code:
A1
Abstract:
The present invention relates to a crystal form of a compound of formula (I), i.e. (2-((5-chloro-2-((2-methoxy-4-(9-methyl-3,9-diaza-spiro[5.5]undecane-3-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. The present invention further relates to a pharmaceutical composition of the crystal form, and the pharmaceutical use thereof and a preparation method therefor.
Inventors:
DING ZHAOFENG (CN)
FU QIANG (CN)
FU QIANG (CN)
Application Number:
PCT/CN2023/109709
Publication Date:
February 08, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
QILU PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/675; C07F9/6561; A61P35/00; C07D471/10
Domestic Patent References:
| WO2016000581A1 | 2016-01-07 |
Foreign References:
| CN110407877A | 2019-11-05 | |||
| CN106928275A | 2017-07-07 |
Other References:
LIU XILE, ZHANG LU, WAN HAIWEN, ZHU ZHENZHEN, JIN JING, QIN YUXIN, MAO WEIFENG, YAN KANG, FANG DOUGLAS, JIANG WEN, HU LIHONG, CHEN: "Discovery and preclinical evaluations of WX-0593, a novel ALK inhibitor targeting crizotinib-resistant mutations", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 66, 1 June 2022 (2022-06-01), Amsterdam NL , pages 128730, XP093135060, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2022.128730
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