Title:
CRYSTAL STRUCTURE OF THE HEPATOCYTE GROWTH FACTOR BETA CHAIN AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2006001911
Kind Code:
A3
Abstract:
The disclosure provides a crystal and crystal structure of the Hepatocyte Growth Factor Beta (HGF ß) Chain, as well as use of the crystal structure in the design, identification, and selection of modulators of HGF or Met activity.
Inventors:
EIGENBROT CHARLES E JR (US)
KIRSCHHOFER DANIEL K (US)
LAZARUS ROBERT A (US)
KIRSCHHOFER DANIEL K (US)
LAZARUS ROBERT A (US)
Application Number:
PCT/US2005/016039
Publication Date:
August 03, 2006
Filing Date:
May 06, 2005
Export Citation:
Assignee:
GENENTECH INC (US)
EIGENBROT CHARLES E JR (US)
KIRSCHHOFER DANIEL K (US)
LAZARUS ROBERT A (US)
EIGENBROT CHARLES E JR (US)
KIRSCHHOFER DANIEL K (US)
LAZARUS ROBERT A (US)
International Classes:
C07K14/475; C07K14/71; G16B15/00; G16B20/20; G16B20/30; G16B20/50
Other References:
NAKAMURA T ET AL: "MOLECULAR CLONING AND EXPRESSION OF HUMAN HEPATOCYTE GROWTH FACTOR", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 342, 23 November 1989 (1989-11-23), pages 440 - 443, XP000652120, ISSN: 0028-0836
DONATE LUIS ENRIQUE ET AL: "Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)", PROTEIN SCIENCE, vol. 3, no. 12, 1994, pages 2378 - 2394, XP002357951, ISSN: 0961-8368
LIETHA DANIEL ET AL: "Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 20, no. 20, 15 October 2001 (2001-10-15), pages 5543 - 5555, XP002357952, ISSN: 0261-4189
PEISACH E ET AL: "Crystal structure of the proenzyme domain of plasminogen.", BIOCHEMISTRY. 24 AUG 1999, vol. 38, no. 34, 24 August 1999 (1999-08-24), pages 11180 - 11188, XP002357953, ISSN: 0006-2960
DATABASE PDB [online] 15 June 2004 (2004-06-15), J.STAMOS, C.WIESMANN: "The Crystal Structure Of Hgf beta -Chain In Complex With The Sema Domain Of The Met Receptor", XP002358237, retrieved from HTTP://WWW.EBI.AC.UK/THORNTON-SRV/DATABASES/PDBSUM/ Database accession no. 1SHY
DONATE LUIS ENRIQUE ET AL: "Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)", PROTEIN SCIENCE, vol. 3, no. 12, 1994, pages 2378 - 2394, XP002357951, ISSN: 0961-8368
LIETHA DANIEL ET AL: "Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 20, no. 20, 15 October 2001 (2001-10-15), pages 5543 - 5555, XP002357952, ISSN: 0261-4189
PEISACH E ET AL: "Crystal structure of the proenzyme domain of plasminogen.", BIOCHEMISTRY. 24 AUG 1999, vol. 38, no. 34, 24 August 1999 (1999-08-24), pages 11180 - 11188, XP002357953, ISSN: 0006-2960
DATABASE PDB [online] 15 June 2004 (2004-06-15), J.STAMOS, C.WIESMANN: "The Crystal Structure Of Hgf beta -Chain In Complex With The Sema Domain Of The Met Receptor", XP002358237, retrieved from HTTP://WWW.EBI.AC.UK/THORNTON-SRV/DATABASES/PDBSUM/ Database accession no. 1SHY
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