CRYSTALLINE FORM OF DOCETAXEL AND PROCESS FOR PREPARATION THEREOF

WIPO Patent Application WO/2012/115402

A2

The present invention relates to a novel anhydrous crystalline form of docetaxel. The novel anhydrous crystalline form of docetaxel according to the present invention is significant since it solves drawbacks the prior art such as stability and accompanying its relative substances increase. Moreover, the present invention provides a process for preparing the anhydrous crystalline form of docetaxel, which can solve the problems such as low yield, long processing time and low purity of the prior art. Also, the present invention provides a process for preparing the crystalline form of docetaxel trihydrates, which can solve the problems such as low yield, difficult reaction condition, long reaction time and time of drying. Therefore the crystalline form of docetaxel trihydrates is produced with the high yield in the mild condition by the process for preparing it.

SUNG SI-YOUNG (KR)
SON BYOUNG-HWA (KR)
RYU KI-MOON (KR)
KIM MOON-SUNG (KR)
KIM DONG-SUNG (KR)
KIM SOON-HOE (KR)

PCT/KR2012/001238

August 30, 2012

February 20, 2012

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DONG A PHARM CO LTD (KR)
SUNG SI-YOUNG (KR)
SON BYOUNG-HWA (KR)
RYU KI-MOON (KR)
KIM MOON-SUNG (KR)
KIM DONG-SUNG (KR)
KIM SOON-HOE (KR)

C07D305/14; A61K31/337; A61P35/00

WO2008051465A2	2008-05-02
WO2009006590A2	2009-01-08
WO2007044950A2	2007-04-19

JP2010138084A

2010-06-24

ROH, Jae-Chull (4F., Halla Building,,641-17Yeoksam-dong,,Gangnam-gu, Seoul 135-909, KR)

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